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Comparison of Biomarkers in Transgenic Alzheimer Rats Using Multi-Shell Diffusion MRI

Fick, Rutger H. J. and Daianu, Madelaine and Pizzolato, Marco and Wassermann, Demian and Jacobs, Russell E. and Thompson, Paul M. and Town, Terrence and Deriche, Rachid (2017) Comparison of Biomarkers in Transgenic Alzheimer Rats Using Multi-Shell Diffusion MRI. In: Computational Diffusion MRI. Springer , Cham, Switzerland, pp. 187-199. ISBN 978-3-319-54129-7.

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In this study, we assessed the evolution of diffusion MRI (dMRI) derived markers from different white matter models as progressive neurodegeneration occurs in transgenic Alzheimer rats (TgF344-AD) at 10, 15 and 24 months. We compared biomarkers reconstructed from Diffusion Tensor Imaging (DTI) , Neurite Orientation Dispersion and Density Imaging (NODDI) and Mean Apparent Propagator (MAP)-MRI in the hippocampus , cingulate cortex and corpus callosum using multi-shell dMRI. We found that NODDI’s dispersion and MAP-MRI’s anisotropy markers consistently changed over time, possibly indicating that these measures are sensitive to age-dependent neuronal demise due to amyloid accumulation. Conversely, we found that DTI’s mean diffusivity, NODDI’s isotropic volume fraction and MAP-MRI’s restriction-related metrics all followed a two-step progression from 10 to 15 months, and from 15 to 24 months. This two-step pattern might be linked with a neuroinflammatory response that may be occurring prior to, or during microstructural breakdown. Using our approach, we are able to provide—for the first time—preliminary and valuable insight on relevant biomarkers that may directly describe the underlying pathophysiology in Alzheimer’s disease.

Item Type:Book Section
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Jacobs, Russell E.0000-0002-1382-8486
Additional Information:© Springer International Publishing AG 2017. First Online: 13 May 2017. This work was partly supported by ANR “MOSIFAH” under ANR-13-MONU-0009-01, the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (ERC Advanced Grant agreement No 694665: CoBCoM) and NIH grants U54 EB020403 and R01NS076794.
Funding AgencyGrant Number
Agence Nationale pour la Recherche (ANR)ANR-13-MONU-0009-01
European Research Council (ERC)694665
NIHU54 EB020403
Subject Keywords:Fractional Anisotropy; Corpus Callosum; Diffusion Tensor Image; Mean Diffusivity; Anisotropy Measure
Record Number:CaltechAUTHORS:20180530-110937820
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:86712
Deposited By: Tony Diaz
Deposited On:30 May 2018 18:30
Last Modified:15 Nov 2021 20:41

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