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Collisional Activation of Large Molecules Is an Efficient Process

Marzluff, Elaine M. and Campbell, Sherrie and Rodgers, M. T. and Beauchamp, J. L. (1994) Collisional Activation of Large Molecules Is an Efficient Process. Journal of the American Chemical Society, 116 (15). pp. 6947-6948. ISSN 0002-7863.

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It is a common perception that as molecules become larger they become inherently more difficult to activate and dissociate in the gas phase, especially under low energy collision induced dissociation (CID) conditions. This difficulty has been attributed both to the inefficiency of the collisional activation process and to the requirement of higher levels of internal excitation to induce dissociation. A serious consequence of this supposition is the implied difficulty of using CID methods to sequence peptides and proteins.

Item Type:Article
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Beauchamp, J. L.0000-0001-8839-4822
Additional Information:© 1994 American Chemical Society. Received March 24, 1994. We gratefully acknowledge the financial support of E.M.M. from a Rainin Fellowship and a NIH-NRSA Human Genome Fellowship, of S.C. from a NIH-NRSA traineeship in biotechnology, and of M.T.R. from a California Institute of Technology Consortium grant. We are indebted to the Beckman Foundation and Institute for support of the research facilities. This work was supported in part by the NSF under Grant CHE-9108318. Funds for instrument development have also been provided by ARPA and the DOD-URI program (ONR-N0014-92-J-1901).
Funding AgencyGrant Number
Rainin Predoctoral FellowshipUNSPECIFIED
NIH Predoctoral FellowshipUNSPECIFIED
Caltech Consortium in Chemistry and Chemical EngineeringUNSPECIFIED
Arnold and Mabel Beckman FoundationUNSPECIFIED
Advanced Research Projects Agency (ARPA)UNSPECIFIED
Office of Naval Research (ONR)N0014-92-J-1901
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Division of Chemistry and Chemical Engineering8936
Issue or Number:15
Record Number:CaltechAUTHORS:20180601-150912894
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Official Citation:Collisional Activation of Large Molecules Is an Efficient Process Elaine M. Marzluff, Sherrie Campbell, M. T. Rodgers, and J. L. Beauchamp Journal of the American Chemical Society 1994 116 (15), 6947-6948 DOI: 10.1021/ja00094a064
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:86757
Deposited By: George Porter
Deposited On:01 Jun 2018 22:53
Last Modified:03 Oct 2019 19:47

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