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The role of lysine-rich histone in the maintenance of chromatin structure in metaphase chromosomes

Mirsky, A. E. and Burdick, C. J. and Davidson, E. H. and Littau, V. C. (1968) The role of lysine-rich histone in the maintenance of chromatin structure in metaphase chromosomes. Proceedings of the National Academy of Sciences of the United States of America, 61 (2). pp. 592-597. ISSN 0027-8424. PMCID PMC225201.

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Dense masses of chromatin are present in the nuclei of many cells during interphase; dense chromatin is also present in the chromosomes of cells during mitosis. Relatively little RNA synthesis takes place in the dense chromatin of interphase cells,(1,2) and apparently none at all in the dense chromatin of metaphase chromosomes. It has been shown that chromatin threads of thymus nuclei are bound together into dense masses by lysine-rich histones.(3) In this paper we present evidence that in metaphase chromosomes, too, chromatin threads are held together by lysine-rich histones.

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Additional Information:© 1968 by the National Academy of Sciences. Communicated August 13, 1968. This research was supported in part by U.S. Public Health Service grant GM-04919.
Funding AgencyGrant Number
U.S. Public Health Service (USPHS)GM-04919
Issue or Number:2
PubMed Central ID:PMC225201
Record Number:CaltechAUTHORS:MIRpnas68
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:8676
Deposited By: Tony Diaz
Deposited On:06 Sep 2007
Last Modified:02 Oct 2019 23:53

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