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Conditioned behavior in Drosophila melanogaster

Quinn, William G. and Harris, William A. and Benzer, Seymour (1974) Conditioned behavior in Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America, 71 (3). pp. 708-712. ISSN 0027-8424. PMCID PMC388082. doi:10.1073/pnas.71.3.708.

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Populations of Drosophila were trained by alternately exposing them to two odorants, one coupled with electric shock. On testing, the flies avoided the shock-associated odor. Pseudoconditioning, excitatory states, odor preference, sensitization, habituation, and subjective bias have been eliminated as explanations. The selective avoidance can be extinguished by retraining. All flies in the population have equal probability of expressing this behavior. Memory persists for 24 hr. Another paradigm has been developed in which flies learn to discriminate between light sources of different color.

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Additional Information:© 1974 by the National Academy of Sciences. Contributed by Seymour Benzer, October 25, 1973. We thank Jeffrey Hall, Martin Heisenberg, Ronald Konopka, and George Zweig for advice and helpful discussions. This work was supported by Grant GB-27228 from the National Science Foundation. W.G.Q. was an NIH postdoctoral fellow. W.A.H. was an Earle C. Anthony fellow and, more recently, a fellow of the Gordon Ross Medical Foundation.
Funding AgencyGrant Number
NIH Postdoctoral FellowshipUNSPECIFIED
Earle C. Anthony Graduate FellowshipUNSPECIFIED
Gordon Ross Medical FoundationUNSPECIFIED
Subject Keywords:learning; memory; odor discrimination; color vision
Issue or Number:3
PubMed Central ID:PMC388082
Record Number:CaltechAUTHORS:QUIpnas74
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Official Citation:Conditioned Behavior in Drosophila melanogaster William G. Quinn, William A. Harris, Seymour Benzer Proceedings of the National Academy of Sciences Mar 1974, 71 (3) 708-712; DOI: 10.1073/pnas.71.3.708
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:8678
Deposited By: Tony Diaz
Deposited On:06 Sep 2007
Last Modified:08 Nov 2021 20:52

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