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Lateral intraparietal area (LIP) is largely effector-specific in free-choice decisions

Christopoulos, Vassilios N. and Kagan, Igor and Andersen, Richard A. (2018) Lateral intraparietal area (LIP) is largely effector-specific in free-choice decisions. Scientific Reports, 8 . Art. No. 8611. ISSN 2045-2322. PMCID PMC5988653. doi:10.1038/s41598-018-26366-9.

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Despite many years of intense research, there is no strong consensus about the role of the lateral intraparietal area (LIP) in decision making. One view of LIP function is that it guides spatial attention, providing a “saliency map” of the external world. If this were the case, it would contribute to target selection regardless of which action would be performed to implement the choice. On the other hand, LIP inactivation has been shown to influence spatial selection and oculomotor metrics in free-choice decisions, which are made using eye movements, arguing that it contributes to saccade decisions. To dissociate between a more general attention role and a more effector specific saccade role, we reversibly inactivated LIP while non-human primates freely selected between two targets, presented in the two hemifields, with either saccades or reaches. Unilateral LIP inactivation induced a strong choice bias to ipsilesional targets when decisions were made with saccades. Interestingly, the inactivation also caused a reduction of contralesional choices when decisions were made with reaches, albeit the effect was less pronounced. These findings suggest that LIP is part of a network for making oculomotor decisions and is largely effector-specific in free-choice decisions.

Item Type:Article
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URLURL TypeDescription CentralArticle
Kagan, Igor0000-0002-1814-4200
Andersen, Richard A.0000-0002-7947-0472
Additional Information:© 2018 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit Received: 27 October 2017; Accepted: 8 May 2018; Published online: 05 June 2018. Data availability: The datasets generated and analyzed during the current study are available from the corresponding author on reasonable request. This work was supported by National Institute of Health (R01 EY007492), the Boswell Foundation, and Swartz Foundation. We thank K. Pejsa for animal care and Dr. V. Shcherbatyuk for computer support. Author Contributions: V.N.C., I.K. and R.A.A. designed the experiment; V.N.C. performed the research, V.N.C. and I.K. analyzed the data, V.N.C., I.K. and R.A.A. wrote the paper. The authors declare no competing interests.
Funding AgencyGrant Number
NIHR01 EY007492
James G. Boswell FoundationUNSPECIFIED
Swartz FoundationUNSPECIFIED
PubMed Central ID:PMC5988653
Record Number:CaltechAUTHORS:20180605-110431147
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:86794
Deposited By: Tony Diaz
Deposited On:05 Jun 2018 18:30
Last Modified:15 Nov 2021 20:42

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