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De Novo Design of Bioactive Protein-Resembling Nanospheres via Dendrimer-Templated Peptide Amphiphile Assembly

Lin, Brian F. and Marullo, Rachel S. and Robb, Maxwell J. and Krogstad, Daniel V. and Antoni, Per and Hawker, Craig J. and Campos, Luis M. and Tirrell, Matthew V. (2011) De Novo Design of Bioactive Protein-Resembling Nanospheres via Dendrimer-Templated Peptide Amphiphile Assembly. Nano Letters, 11 (9). pp. 3946-3950. ISSN 1530-6984. PMCID PMC3223106. https://resolver.caltech.edu/CaltechAUTHORS:20180606-111128037

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Abstract

Self-assembling peptide amphiphiles (PAs) have been extensively used in the development of novel biomaterials. Because of their propensity to form cylindrical micelles, their use is limited in applications where small spherical micelles are desired. Here we present a platform method for controlling the self-assembly of biofunctional PAs into spherical 50 nm particles using dendrimers as shape-directing scaffolds. This templating approach results in biocompatible, stable protein-like assemblies displaying peptides with native secondary structure and biofunctionality.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://dx.doi.org/10.1021/nl202220qDOIArticle
https://pubs.acs.org/doi/suppl/10.1021/nl202220qPublisherSupporting Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223106/PubMed CentralArticle
ORCID:
AuthorORCID
Robb, Maxwell J.0000-0002-0528-9857
Additional Information:© 2011 American Chemical Society. Received: June 30, 2011. Revised: July 27, 2011. Published: August 01, 2011. This work was supported by the MRSEC Program of the NSF under Award No. DMR05-20415, the National Institutes of Health as a Program of Excellence in Nanotechnology under Award Nos. NIH1U01 HL080718, HHSN268201000046C, the CCNE Program of the National Institutes of Health under Award No. NIH1U54 CA119335, and the UC Berkeley College of Engineering. M.J.R thanks the DOE Office of Science for a Graduate Fellowship. The authors thank P. Allen for the artistic renderings, the R. Segalman lab for use of their DLS, and the T. Xu lab for use of their AFM. The authors declare no competing financial interests.
Funders:
Funding AgencyGrant Number
NSFDMR05-20415
NIH1U01 HL080718
NIHHHSN268201000046C
NIH1U54 CA119335
UC Berkeley College of EngineeringUNSPECIFIED
Department of Energy (DOE)UNSPECIFIED
Subject Keywords:biomaterials; dendrimer; Peptide amphiphile; protein analog; self-assembly; templating
Issue or Number:9
PubMed Central ID:PMC3223106
Record Number:CaltechAUTHORS:20180606-111128037
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180606-111128037
Official Citation:De Novo Design of Bioactive Protein-Resembling Nanospheres via Dendrimer-Templated Peptide Amphiphile Assembly Brian F. Lin, Rachel S. Marullo, Maxwell J. Robb, Daniel V. Krogstad, Per Antoni, Craig J. Hawker, Luis M. Campos, and Matthew V. Tirrell Nano Letters 2011 11 (9), 3946-3950 DOI: 10.1021/nl202220q
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:86840
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:06 Jun 2018 22:01
Last Modified:03 Oct 2019 19:49

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