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Functional block copolymer nanoparticles: toward the next generation of delivery vehicles

Robb, Maxwell J. and Connal, Luke A. and Lee, Bongjae F. and Lynd, Nathaniel A. and Hawker, Craig J. (2012) Functional block copolymer nanoparticles: toward the next generation of delivery vehicles. Polymer Chemistry, 3 (6). pp. 1616-1628. ISSN 1759-9954. PMCID PMC4257844. doi:10.1039/C2PY20131C. https://resolver.caltech.edu/CaltechAUTHORS:20180606-133252374

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Abstract

The self-assembly of functional block copolymers (BCPs) into dispersed nanoparticles is a powerful technique for the preparation of novel delivery vehicles with precise control of morphology and architecture. Well-defined BCPs containing an alkyne-functional, biodegradable polylactide (PLA) block were synthesized and conjugated with azide-functional coumarin dyes via copper catalyzed azide alkyne cycloaddition ‘click’ chemistry. Self-assembled nanoparticles with internal nanophase-separated morphologies could then be accessed by carefully controlling the composition of the BCPs and release of the covalently attached model payload was shown to occur under physiological conditions via the degradation of the PLA scaffold. These results demonstrate the potential of self-assembled nanoparticles as modular delivery vehicles with multiple functionalities, nanostructures, and compartmentalized internal morphology.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://dx.doi.org/10.1039/C2PY20131CDOIArticle
http://www.rsc.org/suppdata/py/c2/c2py20131c/c2py20131c.pdfPublisherSupporting Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257844/PubMed CentralArticle
ORCID:
AuthorORCID
Robb, Maxwell J.0000-0002-0528-9857
Hawker, Craig J.0000-0001-9951-851X
Additional Information:© Royal Society of Chemistry 2012. Received 5th March 2012, Accepted 3rd April 2012. This project has been funded in part by the National Heart, Lung, and Blood Institute, National Institutes of Health, under Contract No. HHSN268201000046C (L.A.C., N.A.L., and C.J.H.). This work was also supported by the National Science Foundation (MRSEC Program DMR-1121053 (MRL-UCSB) – B.F.L. and C.J.H. and Chemistry Program CHE-0957492 – M.J.R.). M.J.R. thanks the DOE Office of Science for a graduate fellowship.
Funders:
Funding AgencyGrant Number
NIHHHSN268201000046C
NSFDMR-1121053
NSFCHE-0957492
Department of Energy (DOE)UNSPECIFIED
Issue or Number:6
PubMed Central ID:PMC4257844
DOI:10.1039/C2PY20131C
Record Number:CaltechAUTHORS:20180606-133252374
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180606-133252374
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:86852
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:06 Jun 2018 20:49
Last Modified:15 Nov 2021 20:42

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