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Illuminating small bio-molecules: Stimulated Raman scattering imaging of vibrational tags

Lu, Wei and Wei, Min (2016) Illuminating small bio-molecules: Stimulated Raman scattering imaging of vibrational tags. In: 252nd American Chemical Society National Meeting & Exposition, 21-25 August 2016, Philadelphia, PA.

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Innovations in spectroscopy principles and microscopy technol. have significantly impacted modern biol. and medicine. While most of the contemporary bio-imaging modalities harness electronic transition, nuclear spin or radioactivity, vibrational spectroscopy has not been widely used yet. Here we will discuss an emerging chem. imaging platform, stimulated Raman scattering (SRS) microscopy, which can enhance the otherwise feeble spontaneous Raman eight orders of magnitude by virtue of stimulated emission. When coupled with stable isotopes (e.g., deuterium and 13C) or bioorthogonal chem. moieties (e.g., alkynes), SRS microscopy is well suited for probing in vivo metabolic dynamics of small bio-mols. which cannot be labeled by bulky fluorophores. Phys. principle of the underlying optical spectroscopy and exciting biomedical applications such as imaging lipid metab., protein synthesis, DNA replication, protein degrdn., RNA synthesis, glucose uptake, drug trafficking and tumor metab. will be presented.

Item Type:Conference or Workshop Item (Paper)
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Additional Information:© 2016 American Chemical Society.
Record Number:CaltechAUTHORS:20180608-111309153
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:86917
Deposited By: Tony Diaz
Deposited On:08 Jun 2018 18:22
Last Modified:03 Oct 2019 19:50

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