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Activating Metal Sites for Biological Electron Transfer

Solomon, Edward I. and Hadt, Ryan G. and Snyder, Benjamin E. R. (2016) Activating Metal Sites for Biological Electron Transfer. Israel Journal of Chemistry, 56 (9-10). pp. 649-659. ISSN 0021-2148. PMCID PMC5517049. doi:10.1002/ijch.201600016.

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This review focuses on the unique spectroscopic features of the blue copper active sites. These reflect a novel electronic structure that activates the site for rapid long-range electron transfer in its biological function. The role of the protein in determining the geometric and electronic structure of this site is defined, as is its contribution to function. This has been referred to as the entatic/rack-induced state. These concepts are then extended to cytochrome , which is also determined to be in an entatic state.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Solomon, Edward I.0000-0003-0291-3199
Hadt, Ryan G.0000-0001-6026-1358
Additional Information:© 2016 Wiley VCH. Manuscript received: 24 March 2016. Version of Record online: 01 August 2016. Issue Online 04 October 2016. Special Issue: New Frontiers in Bioinorganic Chemistry This work was supported by a grant from the NIH (DK31450 to E.I.S.).
Funding AgencyGrant Number
Subject Keywords:electron transfer, blue copper, cytochromes, structure-activity relationships, transition metal spectroscopy
Issue or Number:9-10
PubMed Central ID:PMC5517049
Record Number:CaltechAUTHORS:20180612-105511400
Persistent URL:
Official Citation:E. I. Solomon, R. G. Hadt, B. E. R. Snyder, Isr. J. Chem. 2016, 56, 649.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:87001
Deposited By: George Porter
Deposited On:12 Jun 2018 18:10
Last Modified:15 Nov 2021 20:44

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