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Peripheral and Central Nutrient Sensing Underlying Appetite Regulation

Augustine, Vineet and Gokce, Sertan Kutal and Oka, Yuki (2018) Peripheral and Central Nutrient Sensing Underlying Appetite Regulation. Trends in Neurosciences, 41 (8). pp. 526-539. ISSN 0166-2236.

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The precise regulation of fluid and energy homeostasis is essential for survival. It is well appreciated that ingestive behaviors are tightly regulated by both peripheral sensory inputs and central appetite signals. With recent neurogenetic technologies, considerable progress has been made in our understanding of basic taste qualities, the molecular and/or cellular basis of taste sensing, and the central circuits for thirst and hunger. In this review, we first highlight the functional similarities and differences between mammalian and invertebrate taste processing. We then discuss how central thirst and hunger signals interact with peripheral sensory signals to regulate ingestive behaviors. We finally indicate some of the directions for future research.

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Additional Information:© 2018 Elsevier Ltd. Available online 18 June 2018. We thank the Oka lab members and A. Dahanukar for valuable comments. Y.O. is supported by the Searle Scholars Program, the Mallinckrodt Foundation, the McKnight Foundation, the Klingenstein-Simons Foundation, and NIH U01 (U01 NS099717).
Funding AgencyGrant Number
Searle Scholars ProgramUNSPECIFIED
Edward Mallinckrodt, Jr. FoundationUNSPECIFIED
McKnight FoundationUNSPECIFIED
Klingenstein-Simons FoundationUNSPECIFIED
NIHU01 NS099717
Subject Keywords:taste; thirst; hunger; top-down regulation; sensory valence
Issue or Number:8
Record Number:CaltechAUTHORS:20180622-092707469
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Official Citation:Vineet Augustine, Sertan Kutal Gokce, Yuki Oka, Peripheral and Central Nutrient Sensing Underlying Appetite Regulation, Trends in Neurosciences, Volume 41, Issue 8, 2018, Pages 526-539, ISSN 0166-2236, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:87314
Deposited By: Tony Diaz
Deposited On:23 Jun 2018 15:37
Last Modified:03 Oct 2019 19:54

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