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Gene Regulation: Gene Control Network in Development

Ben-Tabou de-Leon, Samadar and Davidson, Eric H. (2007) Gene Regulation: Gene Control Network in Development. Annual Review of Biophysics and Biomolecular Structure, 36 . pp. 191-212. ISSN 1056-8700. doi:10.1146/annurev.biophys.35.040405.102002.

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Controlling the differential expression of many thousands of genes is the most fundamental task of a developing organism. It requires an enormous computational device that has the capacity to process in parallel a vast number of regulatory inputs in the various cells of the embryo and come out with regulatory outputs that are tissue specific. The regulatory genome constitutes this computational device, comprising many thousands of processing units in the form of cis-regulatory modules. The interconnected cis-regulatory modules that control regulatory gene expression create a network that is the underlying mechanism of specification. In this review we use the gene regulatory network that governs endomesoderm specification in the sea urchin embryo to demonstrate the salient features of developmental gene regulatory networks and illustrate the information processing that is done by the regulatory sequences.

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Additional Information:"Reprinted, with permission, from the Annual Review of Biophysics and Biomolecular Structure, Volume 36 copyright 2007 by Annual Reviews," First published online as a Review in Advance on January 30, 2007 We thank Joel Smith, Paola Oliveri, and Veronica Hinman for insightful discussions and critical comments. Research was supported by National Institutes of Health grant HD37105. Smadar Ben-Tabou de-Leon was supported by the Human Frontier Science Program Organization.
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Human Frontier Science Program OrganizationUNSPECIFIED
Subject Keywords:gene regulatory networks, cis-regulatory modules, sea urchin, transcription factors
Record Number:CaltechAUTHORS:LEOarbbs07
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:8735
Deposited By: Archive Administrator
Deposited On:11 Sep 2007
Last Modified:08 Nov 2021 20:52

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