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Heat shock and Phenocopy induction in Drosophila

Mitchell, Herschel K. and Lipps, Loveriza S. (1978) Heat shock and Phenocopy induction in Drosophila. Cell, 15 (3). pp. 907-918. ISSN 0092-8674. doi:10.1016/0092-8674(78)90275-1.

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Differentiation of the single cells that yield bristles and hairs in Drosophila has been examined by studies of phenocopies induced by heat shock. Phenocopies that resemble the mutants hook and javelin are produced by application of the stress within narrow and specific time ranges during metamorphosis. Double phenocopies can be induced by successive heat shocks at appropriate time intervals. Phenocopy production may be related to heat shock effects on RNA synthesis through a feedback inhibition of transcription by heat shock proteins.

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Additional Information:© 1978 MIT. Received July 5, 1978; revised August 28, 1978. This work was supported in part by a grant from the NSF and in part by a BRSG grant. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
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Issue or Number:3
Record Number:CaltechAUTHORS:20180629-102633504
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Official Citation:Herschel K. Mitchell, Loveriza S. Lipps, Heat shock and Phenocopy induction in Drosophila, Cell, Volume 15, Issue 3, 1978, Pages 907-918, ISSN 0092-8674, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:87468
Deposited By: Tony Diaz
Deposited On:29 Jun 2018 17:48
Last Modified:15 Nov 2021 20:48

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