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Directional sensitivity of individual vertebrate hair cells to controlled deflection of their hair bundles

Shotwell, S. L. and Jacobs, R. and Hudspeth, A. J. (1981) Directional sensitivity of individual vertebrate hair cells to controlled deflection of their hair bundles. Annals of the New York Academy of Sciences, 374 (1). pp. 1-10. ISSN 0077-8923. https://resolver.caltech.edu/CaltechAUTHORS:20180702-142631690

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Abstract

Among the most striking and consistent morphological features of vertebrate hair cells is the geometrical arrangement of their mechanosensitive organelles, the hair bundles. These structures each consist of 30-200 microvilluslike stereocilia and a single, eccentrically placed, axonemal kinocilium. Three geometrical features of hair bundles are widespread, if not universal. First, the stereocilia and kinocilium are inserted into the cellular apex in a regular, hexagonal array. Second, the lengths of stereocilia increase monotonically from one edge of the hair bundle to the other, but are approximately equal within a row of stereocilia across the hair bundle. Finally, the kinocilium is located at the edge of the hair bundle at which the longest stereocilia occur. Distortions of these features may occur; for example, the spacing of stereocilia is not absolutely uniform in some hair cells, but varies from one edge of the hair bundle to the other. Hair bundles become progressively distorted and asymmetrical as the apex of the mammalian cochlea is approached. The kinocilium, although present in ontogeny, is lost from some hair cells in mammalian cochleas. Even in these exceptional cases, however, the general pattern of arrangement of the hair bundle is evident.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1111/j.1749-6632.1981.tb30854.x DOIArticle
ORCID:
AuthorORCID
Jacobs, R.0000-0002-1382-8486
Additional Information:© 1981 Wiley. This research was supported by National Institutes of Health Grants NS‐13154 and GM‐00086 and by funds from the William Randolph Hearst, Ann Peppers, and Pew Foundations. The authors thank Dr. D. P. Corey for comments on the manuscript.
Funders:
Funding AgencyGrant Number
NIHNS-13154
NIHGM-00086
William Randolph Hearst FoundationUNSPECIFIED
Ann Peppers FoundationUNSPECIFIED
Pew FoundationUNSPECIFIED
Issue or Number:1
Record Number:CaltechAUTHORS:20180702-142631690
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180702-142631690
Official Citation:Shotwell, S. L., Jacobs, R. and Hudspeth, A. J. (1981), DIRECTIONAL SENSITIVITY OF INDIVIDUAL VERTEBRATE HAIR CELLS TO CONTROLLED DEFLECTION OF THEIR HAIR BUNDLES. Annals of the New York Academy of Sciences, 374: 1-10. doi:10.1111/j.1749-6632.1981.tb30854.x
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:87528
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:03 Jul 2018 18:01
Last Modified:03 Oct 2019 19:57

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