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Effects of dosage alterations at the per locus on the period of the circadian clock of Drosophila

Smith, Randall F. and Konopka, Ronald J. (1982) Effects of dosage alterations at the per locus on the period of the circadian clock of Drosophila. Molecular Genetics and Genomics, 185 (1). pp. 30-36. ISSN 1617-4615. http://resolver.caltech.edu/CaltechAUTHORS:20180702-151816675

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Abstract

The normal 24-h period of the circadian rhythms of locomotor activity and eclosion of Drosophila melanogaster is altered by changes in per gene dosage. Females with only one dose of per^+ or per^ s (the 19-h short-period mutant allele) or per^1 (the 29-h long-period mutant allele) have periods which are about 1–2 h longer than the corresponding females with 2 doses. Females with 3 doses of per^+ and males with 2 doses of per^+ or per ^s have periods which are 1/2 to 1 h shorter than the corresponding individuals without the extra dose. Males with three per^+ doses have periods which are about 1.5 h shorter than wild-type males; additional per^+ doses do not shorten period further. The observation that decreased per dosage lengthens period while increased dosage shortens period suggests that the long- and short-period mutations alter period by respectively decreasing and increasing per gene or gene product activity. The per^+ dosage results and the complementation behavior of per s indicate that the hypermorphic phenotype of per^ s results from increased activity of the per^ s gene product rather than an overproduction of per^+ product. This is the first report of such a mutant action in Drosophila.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1007/BF00333786DOIArticle
Additional Information:© 1982 Springer-Verlag. Received: 01 December 1981.
Subject Keywords:Gene Product; Locomotor Activity; Circadian Rhythm; Product Activity; Mutant Allele
Record Number:CaltechAUTHORS:20180702-151816675
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20180702-151816675
Official Citation:Smith, R.F. & Konopka, R.J. Molec Gen Genet (1982) 185: 30. https://doi.org/10.1007/BF00333786
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:87530
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:03 Jul 2018 17:57
Last Modified:03 Jul 2018 17:57

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