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Starburst Dendrimers: Molecular‐Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter

Tomalia, Donald A. and Naylor, Adel M. and Goddard, William A., III (1990) Starburst Dendrimers: Molecular‐Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter. Angewandte Chemie International Edition in English, 29 (2). pp. 138-175. ISSN 0570-0833. doi:10.1002/anie.199001381.

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Starburst dendrimers are three‐dimensional, highly ordered oligomeric and polymeric compounds formed by reiterative reaction sequences starting from smaller molecules—“initiator cores” such as ammonia or pentaerythritol. Protecting group strategies are crucial in these syntheses, which proceed via discrete “Aufbau” stages referred to as generations. Critical molecular design parameters (CMDPs) such as size, shape, and surface chemistry may be controlled by the reactions and synthetic building blocks used. Starburst dendrimers can mimic certain properties of micelles and liposomes and even those of biomolecules and the still more complicated, but highly organized, building blocks of biological systems. Numerous applications of these compounds are conceivable, particularly in mimicking the functions of large biomolecules as drug carriers and immunogens. This new branch of “supramolecular chemistry” should spark new developments in both organic and macromolecular chemistry.

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Goddard, William A., III0000-0003-0097-5716
Additional Information:© 1990 by VCH Verlagsgesellschaft mbH, Germany. Received: February 3, 1989 [A 746 IE] German version: Angew. Chem. 102 (1990) 119 We wish to express sincere thanks to numerous colleagues both past and present who have contributed so much to the work cited in this paper. We are especially grateful for useful discussions with Professors P. de Gennes (Collkge de France), G. Newkome (University of South Florida), N. Turro (Columbia University), H. Hall (University of Arizona), D. Tirrell (University of Massachusetts), and D. Meier (Michigan Molecular Institute), as well as Dr. D. M . Hedstrand and Dr. L. R. Wilson (Dow Chemical Company). Generous support for one of us (D.A.T.) from the Michigan Molecular Institute and the New Energy and Technology Development Organization (NEDO) of the Ministry of International Trade and Industry of Japan (MITI) assisted significantly in certain critical synthetic and theoretical efforts. The computer simulations were funded by a contract from Energy Conversion and Utilization Technologies Program of the Department of Energy (USA). The computer equipment used was funded by a contract (No. NOOO14-86-K-0735) from Defense Advanced Research Projects Agency, Office of Naval Research, and by a grant (No. DMR-94-21119) from the Division of Materials Research of the National Science Foundation, Materials Research Groups (USA).
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Michigan Molecular InstituteUNSPECIFIED
Ministry of International Trade and Industry (Japan)UNSPECIFIED
Department of Energy (DOE)UNSPECIFIED
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Office of Naval Research (ONR)N00014-86-K-0735
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Deposited By: Donna Wrublewski
Deposited On:05 Jul 2018 20:39
Last Modified:15 Nov 2021 20:49

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