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Redox Sensitive Metastable DNA Junctions for Multivalent Delivery of Therapeutics

Salah, Marwa Ben Haj and Han, Si-Ping and Scherer, Lisa and Goddard, William A., III and Rossi, John J. (2018) Redox Sensitive Metastable DNA Junctions for Multivalent Delivery of Therapeutics. Molecular Therapy, 26 (5). p. 145. ISSN 1525-0016. https://resolver.caltech.edu/CaltechAUTHORS:20180706-155708788

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Abstract

Delivery is one of the most challenging technical barriers for effective use of oligonucleotide therapeutics (OT) in vivo. Recent studies have demonstrated that simple nucleic acid nanostructures can act as molecularly uniform, multivalent carrier platforms for therapeutic cargos and cell targeting ligands. Although this approach has significant promise, much remains unknown regarding the effects of carrier nanostructures on the (I) in vivo distribution and pharmacokinetics, (II) cell entry and endosomal escape and (III) cytoplasmic processing of therapeutic cargos such as small interfering RNAs (siRNA).


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.ymthe.2018.05.001DOIAbstracts
ORCID:
AuthorORCID
Han, Si-Ping0000-0002-2213-4953
Goddard, William A., III0000-0003-0097-5716
Additional Information:© 2018 American Society of Gene & Cell Therapy. Available online 9 May 2018.
Issue or Number:5
Record Number:CaltechAUTHORS:20180706-155708788
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180706-155708788
Official Citation:ASGCT 21st Annual Meeting Abstracts, Molecular Therapy, Volume 26, Issue 5, Supplement 1, 2018, Pages 1-459, ISSN 1525-0016, https://doi.org/10.1016/j.ymthe.2018.05.001. (http://www.sciencedirect.com/science/article/pii/S1525001618302041)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:87625
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:06 Jul 2018 23:14
Last Modified:24 Nov 2020 00:39

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