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The site of ribonucleic acid synthesis in the isolated nucleus

Rho, Joon H. and Bonner, James (1961) The site of ribonucleic acid synthesis in the isolated nucleus. Proceedings of the National Academy of Sciences of the United States of America, 47 (10). pp. 1611-1619. ISSN 0027-8424.

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There is still controversy concerning the primary site of RNA synthesis in the cell.(1) When tissues are radioautographed after administration of radioactive inorganic phosphorus or radioactive RNA(2) precursors such as tritiated uridine or cytidine, it is commonly observed that radioactivity appears in the nucleus first and in the cytoplasm later. It has furthermore been shown that isolated nuclei of both animal(3) and plant(4) material are able to synthesize RNA in vitro but that enucleated cytoplasm is unable to carry on such synthesis.(5) Although the problem of whether or not RNA is synthesized in both nucleus and cytoplasm is not completely understood,(6-8) there is increasing cytological evidence that a substantial portion of the cytoplasmic RNA is synthesized in the nucleus (9-17) and subsequently migrates to the cytoplasm.

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Additional Information:© 1961 by the National Academy of Sciences. Communicated August 9, 1961. We wish to acknowledge the technical assistance of Mr. Robert Hayes and the counsel of Drs. Max Birnstiel and Clifford Sato. Report of work supported in part by the National Institutes of Health, U.S. Public Health Service, Grant No. RG-5143. [J.H.R. was] [s]upported by Visiting Scientists Program, National Academy of Sciences.
Issue or Number:10
Record Number:CaltechAUTHORS:RHOpnas61
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:8766
Deposited By: Tony Diaz
Deposited On:15 Sep 2007
Last Modified:02 Oct 2019 23:54

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