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Optofluidic microscope: a complete on-chip imaging device

Cui, Xiquan and Heng, Xin and Yang, Changhuei (2008) Optofluidic microscope: a complete on-chip imaging device. In: Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VI. Proceedings of SPIE. No.6859. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 68590Y. ISBN 9780819470348. http://resolver.caltech.edu/CaltechAUTHORS:20180711-110458635

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Abstract

This paper reports a complete on-chip high resolution lensless imaging device based on the optofluidic microscopy method, which can form a vital optical microscopy component in a wide range of lab-on-a-chip systems. This imaging device does not use any lens elements and yet is capable of resolution comparable to that of a conventional microscope with a 20× objective. We demonstrate the use of the device for Caenorhabditis elegans and microsphere imaging at a resolution of ~ 1 μm with an imaging time of ~2 sec. The fabrication of this on-chip imaging device is fully compatible with existing semiconductor and microfluidic technologies, so the device can be massively fabricated and integrated into microsystems to form compact and low-cost total analysis systems for biological and colloidal studies.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.764957DOIArticle
ORCID:
AuthorORCID
Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2008 Society of Photo-Optical Instrumentation Engineers (SPIE). We are grateful for the generous help from Professor Axel Scherer. The assistance from Caltech Watson cleanroom is well appreciated. This project is funded by DARPA’s center for optofluidic integration and Coulter Foundation Career Award.
Funders:
Funding AgencyGrant Number
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Wallace H. Coulter FoundationUNSPECIFIED
Subject Keywords:Microscope, optofluidics, cytometry, microorganism, colloid, biophotonics, microfluidics
Record Number:CaltechAUTHORS:20180711-110458635
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20180711-110458635
Official Citation:Xiquan Cui, Xin Heng, Changhuei Yang, "Optofluidic microscope: a complete on-chip imaging device", Proc. SPIE 6859, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VI, 68590Y (29 February 2008); doi: 10.1117/12.764957; https://doi.org/10.1117/12.764957
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:87757
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:11 Jul 2018 18:18
Last Modified:11 Jul 2018 18:18

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