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Improved in vivo imaging of human blood circulation in the chorioretinal complex using phase variance method with new phase stabilized 1 μm swept-source optical coherence tomography (pv-SSOCT)

Poddar, Raju and Kim, Dae Yu and Werner, John S. and Zawadzki, Robert J. (2014) Improved in vivo imaging of human blood circulation in the chorioretinal complex using phase variance method with new phase stabilized 1 μm swept-source optical coherence tomography (pv-SSOCT). In: Ophthalmic Technologies XXIV. Proceedings of SPIE. No.8930. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 89300X. ISBN 9780819498434. http://resolver.caltech.edu/CaltechAUTHORS:20180713-111318398

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Abstract

We demonstrate the feasibility of our newly developed phase stabilized high-speed (100 kHz A-scans/s) 1 μm sweptsource optical coherence tomography (SSOCT) system with the phase-variance based motion contrast method for visualization of human chorioretinal complex microcirculation. Compared to our previously reported spectral domain (spectrometer based) phase-variance (pv)-SDOCT system it has advantages of higher sensitivity, reduced fringe washout for high blood flow speeds and deeper penetration in choroid. High phase stability SSOCT imaging was achieved by using a computationally efficient phase stabilization approach. This process does not require additional calibration hardware and complex numerical procedures. Our phase stabilization method is simple and can be employed in a variety of SS-OCT systems. Examples of vasculature in the chorioretinal complex imaged by pv-SSOCT is presented and compared to retinal images of the same volunteers acquired with fluorescein angiography (FA) and indocyanine green angiography (ICGA).


Item Type:Book Section
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URLURL TypeDescription
https://doi.org/10.1117/12.2040186DOIArticle
Additional Information:© 2014 Society of Photo-Optical Instrumentation Engineers (SPIE). We gratefully acknowledge the contributions of VSRI UC Davis lab members and the Biological Imaging Center at the California Institute of Technology for supporting the phase-variance post-processing software. This research was supported by the National Eye Institute (EY 014743) and Research to Prevent Blindness (RPB).
Funders:
Funding AgencyGrant Number
NIHEY 014743
Research to Prevent BlindnessUNSPECIFIED
Subject Keywords:Optical coherence tomography; Retinal blood flow; Ophthalmic optics and devices; Ophthalmology; Medical and biological imaging; Medical optics instrumentation
Record Number:CaltechAUTHORS:20180713-111318398
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20180713-111318398
Official Citation:Raju Poddar, Dae Yu Kim, John S. Werner, Robert J. Zawadzki, "Improved in vivo imaging of human blood circulation in the chorioretinal complex using phase variance method with new phase stabilized 1 μm swept-source optical coherence tomography (pv-SSOCT)", Proc. SPIE 8930, Ophthalmic Technologies XXIV, 89300X (28 February 2014); doi: 10.1117/12.2040186; https://doi.org/10.1117/12.2040186
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:87825
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:16 Jul 2018 16:21
Last Modified:16 Jul 2018 16:21

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