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A high-resolution optofluidic microscope with optical tweezer actuation

Heng, Xin and Hsiao, Edward and Psaltis, Demetri and Yang, Changhuei (2007) A high-resolution optofluidic microscope with optical tweezer actuation. In: Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V. Proceedings of SPIE. No.6441. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 644113. ISBN 9780819465542.

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In this paper, we will report our recent development of a new type of OptoFluidic Microscope (OFM) that is capable of delivering resolution beyond the diffraction limit of light. Accurate control of the sample translation is accomplished by adopting an optical tweezer scanner into the system. During the image acquisition, a two-dimensional nanoaperture array defined on a thin aluminum film acts as an array of ultra-fine illumination sources. The imaging system is tested and demonstrated by using polystyrene beads and green algae (Chlamydomonas). Properties of the system are reported and discussed.

Item Type:Book Section
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Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2007 Society of Photo-Optical Instrumentation Engineers (SPIE). We are grateful to Xiquan Cui, Zahid Yaqoob, Jigang Wu and Lap Man Lee from Caltech for their generous help. We thank UCLA’s Nanolab and Caltech’s nanofabrication group (Dr. Scherer) for their assistance in fabrication. This work was funded by DARPA Center for Optofluidic Integration (California Institute of Technology) and Coulter Foundation Career Award (funding).
Funding AgencyGrant Number
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Wallace H. Coulter FoundationUNSPECIFIED
Series Name:Proceedings of SPIE
Issue or Number:6441
Record Number:CaltechAUTHORS:20180716-110718056
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Official Citation:Xin Heng, Edward Hsiao, Demetri Psaltis, Changhuei Yang, "A high-resolution optofluidic microscope with optical tweezer actuation", Proc. SPIE 6441, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V, 644113 (19 February 2007); doi: 10.1117/12.701728;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:87881
Deposited By: George Porter
Deposited On:16 Jul 2018 22:49
Last Modified:03 Oct 2019 20:00

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