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Protein-based molecular contrast optical coherence tomography

Yang, Changhuei and Choma, Michael A. and Lamb, Laura E. and Simon, John D. and Izatt, Joseph A. (2004) Protein-based molecular contrast optical coherence tomography. In: Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII. Proceedings of SPIE. No.5316. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, pp. 85-90. ISBN 0819452246.

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We describe a novel technique for contrast enhancement in optical coherence tomography (OCT) which uses optically switchable protein based chromophores. Photosensitive proteins, such as bacteriorhodopsin and phytochrome, are promising OCT molecular contrast agents by reason of their remarkably low transition activation intensities compatible with in vivo imaging, and their potential for use as genetically expressible markers for molecular imaging. This study details the use of a novel optical switch suppression scheme which uses the absorption change between the two state groups of phytochrome to extract concentration and distribution information of the contrast agent within a target sample.

Item Type:Book Section
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Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2004 Society of Photo-Optical Instrumentation Engineers (SPIE). This research was supported by NIH grant no. EB000243.
Funding AgencyGrant Number
Subject Keywords:molecular contrast, optical coherence tomography. protein, phytochrome
Series Name:Proceedings of SPIE
Issue or Number:5316
Record Number:CaltechAUTHORS:20180716-163516918
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Official Citation:Changhuei Yang, Michael A. Choma, Laura E. Lamb, John D. Simon, Joseph A. Izatt, "Protein-based molecular contrast optical coherence tomography", Proc. SPIE 5316, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII, (1 July 2004); doi: 10.1117/12.531353;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:87901
Deposited By: George Porter
Deposited On:17 Jul 2018 15:57
Last Modified:16 Nov 2021 00:21

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