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Protein-based molecular contrast optical coherence tomography

Yang, Changhuei and Choma, Michael A. and Lamb, Laura E. and Simon, John D. and Izatt, Joseph A. (2004) Protein-based molecular contrast optical coherence tomography. In: Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII. Proceedings of SPIE. No.5316. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, pp. 85-90. ISBN 0819452246. http://resolver.caltech.edu/CaltechAUTHORS:20180716-163516918

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Abstract

We describe a novel technique for contrast enhancement in optical coherence tomography (OCT) which uses optically switchable protein based chromophores. Photosensitive proteins, such as bacteriorhodopsin and phytochrome, are promising OCT molecular contrast agents by reason of their remarkably low transition activation intensities compatible with in vivo imaging, and their potential for use as genetically expressible markers for molecular imaging. This study details the use of a novel optical switch suppression scheme which uses the absorption change between the two state groups of phytochrome to extract concentration and distribution information of the contrast agent within a target sample.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.531353DOIArticle
http://resolver.caltech.edu/CaltechAUTHORS:YANol04bRelated ItemJournal Article
ORCID:
AuthorORCID
Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2004 Society of Photo-Optical Instrumentation Engineers (SPIE). This research was supported by NIH grant no. EB000243.
Funders:
Funding AgencyGrant Number
NIHEB000243
Subject Keywords:molecular contrast, optical coherence tomography. protein, phytochrome
Record Number:CaltechAUTHORS:20180716-163516918
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20180716-163516918
Official Citation:Changhuei Yang, Michael A. Choma, Laura E. Lamb, John D. Simon, Joseph A. Izatt, "Protein-based molecular contrast optical coherence tomography", Proc. SPIE 5316, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII, (1 July 2004); doi: 10.1117/12.531353; https://doi.org/10.1117/12.531353
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:87901
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:17 Jul 2018 15:57
Last Modified:17 Jul 2018 15:57

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