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Magnetic guidestar assisted light focusing through scattering media

Ruan, Haowen and Brake, Joshua and Jang, Mooseok and Yang, Changhuei (2017) Magnetic guidestar assisted light focusing through scattering media. In: Adaptive Optics and Wavefront Control for Biological Systems III. Proceedings of SPIE. No.10073. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 100730I. ISBN 9781510605879. http://resolver.caltech.edu/CaltechAUTHORS:20180717-083621756

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Abstract

Optical scattering of biological tissue limits the working depth of conventional biomedical optics, which relies on the detection of ballistic photons. Recent developed optical phase conjugation (OPC) technique breaks through this depth limit by harnessing the scattered photons and shaping an optical wavefront that can “undo” the optical scattering. The OPC system measures the complex light field exiting the tissue and reconstructs a phase conjugated copy of the measured wavefront, which propagates in the reversed direction to the source of the light. To focus light inside a scattering medium, an embedded light source or “guidestar” is often required. Therefore, developing guidestar mechanisms plays an important role in advancing the OPC technique for deep tissue optical focusing and imaging. In addition to having strong optical modulation efficiency and compact size, a favorable guidestar for biomedical applications should also have good biocompatibility, fast response time, and be noninvasive or require only minimally invasive procedure. While a number of guidestar mechanisms have been developed and showed promising for various biomedical applications, they all have their own limitations. We have been developing new guidestars and tailoring them to meet the need for biomedical imaging and therapies. We are going to present our recent progress in novel guidestar development, compare them with established guidestar mechanisms, and discuss their potential in biomedical applications.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.2252997DOIArticle
ORCID:
AuthorORCID
Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2017 Society of Photo-optical Instrumentation Engineers (SPIE).
Record Number:CaltechAUTHORS:20180717-083621756
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20180717-083621756
Official Citation:Haowen Ruan, Joshua Brake, Mooseok Jang, Changhuei Yang, "Magnetic guidestar assisted light focusing through scattering media (Conference Presentation)", Proc. SPIE 10073, Adaptive Optics and Wavefront Control for Biological Systems III, 100730I (24 April 2017); doi: 10.1117/12.2252997; https://doi.org/10.1117/12.2252997
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:87911
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:17 Jul 2018 18:39
Last Modified:17 Jul 2018 18:39

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