Yang, Changhuei and Rao, K. Divakar and Choma, Michael and Yazdanfar, Siavash and Rollins, Andrew M. and Izatt, Joseph A. (2003) Molecular contrast in optical coherence tomography using a pump-probe technique and a optical switch suppression technique. In: Optical Coherence Tomography and Coherence Techniques. Proceedings of SPIE. No.5140. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, pp. 95-100. ISBN 0819467715. https://resolver.caltech.edu/CaltechAUTHORS:20180719-110832273
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Abstract
We describe two novel techniques for contrast enhancement in optical coherence tomography (OCT) which enables molecular specific imaging. The first, a pump-probe technique, is employed in which a pulsed pump laser is tuned to ground-state absorption in a molecule of interest. The location of the target molecule population is derived from the resulting transient absorption of OCT sample arm light acting as probe light. Preliminary results exhibiting contrast enhancement in cross-sectional OCT images using methylene blue dye are presented. The second method is an optical switch suppression technique based on the use of a transmembrane protein called bacteriorhodopsin. Initial experiments indicate that biochemical optical switches, such as bacteriorhodopsin, are excellent contrast agent candidates for molecular contrast OCT.
Item Type: | Book Section | ||||||
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Additional Information: | © 2003 Society of Photo-Optical Instrumentation Engineers (SPIE). | ||||||
Subject Keywords: | OCT, molecular contrast, pump-probe spectroscopy | ||||||
Series Name: | Proceedings of SPIE | ||||||
Issue or Number: | 5140 | ||||||
DOI: | 10.1117/12.501007 | ||||||
Record Number: | CaltechAUTHORS:20180719-110832273 | ||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20180719-110832273 | ||||||
Official Citation: | Changhuei Yang, K. Divakar Rao, Michael Choma, Siavash Yazdanfar, Andrew M. Rollins, Joseph A. Izatt, "Molecular contrast in optical coherence tomography using a pump-probe technique and a optical switch suppression technique", Proc. SPIE 5140, Optical Coherence Tomography and Coherence Techniques, (2 October 2003); doi: 10.1117/12.501007; https://doi.org/10.1117/12.501007 | ||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
ID Code: | 87998 | ||||||
Collection: | CaltechAUTHORS | ||||||
Deposited By: | George Porter | ||||||
Deposited On: | 19 Jul 2018 19:49 | ||||||
Last Modified: | 16 Nov 2021 00:22 |
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