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Molecular contrast in optical coherence tomography using a pump-probe technique and a optical switch suppression technique

Yang, Changhuei and Rao, K. Divakar and Choma, Michael and Yazdanfar, Siavash and Rollins, Andrew M. and Izatt, Joseph A. (2003) Molecular contrast in optical coherence tomography using a pump-probe technique and a optical switch suppression technique. In: Optical Coherence Tomography and Coherence Techniques. Proceedings of SPIE. No.5140. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, pp. 95-100. ISBN 0819467715. https://resolver.caltech.edu/CaltechAUTHORS:20180719-110832273

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Abstract

We describe two novel techniques for contrast enhancement in optical coherence tomography (OCT) which enables molecular specific imaging. The first, a pump-probe technique, is employed in which a pulsed pump laser is tuned to ground-state absorption in a molecule of interest. The location of the target molecule population is derived from the resulting transient absorption of OCT sample arm light acting as probe light. Preliminary results exhibiting contrast enhancement in cross-sectional OCT images using methylene blue dye are presented. The second method is an optical switch suppression technique based on the use of a transmembrane protein called bacteriorhodopsin. Initial experiments indicate that biochemical optical switches, such as bacteriorhodopsin, are excellent contrast agent candidates for molecular contrast OCT.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.501007DOIArticle
ORCID:
AuthorORCID
Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2003 Society of Photo-Optical Instrumentation Engineers (SPIE).
Subject Keywords:OCT, molecular contrast, pump-probe spectroscopy
Series Name:Proceedings of SPIE
Issue or Number:5140
Record Number:CaltechAUTHORS:20180719-110832273
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180719-110832273
Official Citation:Changhuei Yang, K. Divakar Rao, Michael Choma, Siavash Yazdanfar, Andrew M. Rollins, Joseph A. Izatt, "Molecular contrast in optical coherence tomography using a pump-probe technique and a optical switch suppression technique", Proc. SPIE 5140, Optical Coherence Tomography and Coherence Techniques, (2 October 2003); doi: 10.1117/12.501007; https://doi.org/10.1117/12.501007
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:87998
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:19 Jul 2018 19:49
Last Modified:03 Oct 2019 20:01

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