CaltechAUTHORS
  A Caltech Library Service

The Study of Cell Dynamics with a Novel Phase Referenced Low Coherence Interferometer with sub-wavelength and sub-hertz Sensitivity

Yang, Changhuei and Wax, Adam and Badizadegan, Kamran and Dasari, Ramachandra R. and Feld, Michael S. (2002) The Study of Cell Dynamics with a Novel Phase Referenced Low Coherence Interferometer with sub-wavelength and sub-hertz Sensitivity. In: Coherence Domain Optical Methods in Biomedical Science and Clinical Applications VI. Proceedings of SPIE. No.4619. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, pp. 202-209. ISBN 0819447560. https://resolver.caltech.edu/CaltechAUTHORS:20180719-112222225

[img] PDF - Published Version
See Usage Policy.

219Kb

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20180719-112222225

Abstract

We report the use of a highly sensitive phase based motion measurement technique to study the correlation of cellular metabolic rate with cellular motions. The technique is based on a modified Michelson interferometer with a composite laser beam of 1550 nm low coherence light and 775 nm CW light. In this system, motional artifacts from vibrations in the interferometer are completely eliminated. We demonstrate that the system is sensitive to motions as small as 3.6 nm and velocities as small as 1 nm/s. Using the system, we show that the cellular motions are strongly dependent on the ambient temperature. We observe that the dependency does not conform to Brownian motion predictions but instead appears to correlate with the optical ambient temperature that the cells have evolved to operate in.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.470484DOIArticle
ORCID:
AuthorORCID
Yang, Changhuei0000-0001-8791-0354
Alternate Title:Cell dynamics with a novel phase referenced low-coherence interferometer with sub-wavelength and sub-hertz sensitivity
Additional Information:© 2002 Society of Photo-Optical Instrumentation Engineers (SPIE).
Subject Keywords:coherence, interferometry, cell, dynamics, metabolic, phase, harmonic
Series Name:Proceedings of SPIE
Issue or Number:4619
Record Number:CaltechAUTHORS:20180719-112222225
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180719-112222225
Official Citation:Changhuei Yang, Adam Wax, Kamran Badizadegan, Ramachandra R. Dasari, Michael S. Feld, "Cell dynamics with a novel phase referenced low-coherence interferometer with sub-wavelength and sub-hertz sensitivity", Proc. SPIE 4619, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications VI, (14 June 2002); doi: 10.1117/12.470484; https://doi.org/10.1117/12.470484
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:88001
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:19 Jul 2018 20:42
Last Modified:03 Oct 2019 20:02

Repository Staff Only: item control page