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A protein intermediary in the interaction of a hormone with the genome

Matthysse, Ann G. and Phillips, Cornell (1969) A protein intermediary in the interaction of a hormone with the genome. Proceedings of the National Academy of Sciences of the United States of America, 63 (3). pp. 897-903. ISSN 0027-8424.

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The increased rate of RNA synthesis by target cells caused by the plant hormone auxin has been studied as an example of hormonal regulation of transcription. The hormone does not interact directly with chromatin but requires a protein mediator. In the presence of this mediator, auxin increases the rate of RNA synthesis both by isolated plant nuclei and by isolated chromatin. This increased rate of RNA synthesis occurs even in the presence of saturating amounts of RNA polymerase. The hormone and protein do not affect the rate of RNA synthesis if pure DNA is used as the template. The results suggest that auxin plus the protein increase the rate of RNA synthesis by making an increased portion of the genome available for transcription.

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Additional Information:© 1969 by the National Academy of Sciences. Communicated by James Bonner, May 12, 1969. We gratefully acknowledge the encouragement and advice of Dr. James Bonner in whose laboratory this research was carried out. We thank Mrs. Ludia Brown for technical assistance. This work was supported in part by a U.S. Public Health Service postdoctoral fellowship and by USPHS grants (GM-86 and GM-13762).
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Record Number:CaltechAUTHORS:MATpnas69
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:8801
Deposited By: Tony Diaz
Deposited On:18 Sep 2007
Last Modified:02 Oct 2019 23:54

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