Chang, Sukbok and Grubbs, Robert H. (1998) A Highly Efficient and Practical Synthesis of Chromene Derivatives Using Ring-Closing Olefin Metathesis. Journal of Organic Chemistry, 63 (3). pp. 864-866. ISSN 0022-3263. doi:10.1021/jo9712198. https://resolver.caltech.edu/CaltechAUTHORS:20180720-153948239
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Abstract
Chromenes (2H-1-benzopyran derivatives) have been widely employed as important intermediates in the synthesis of many natural products and medicinal agents. There has been recent interest in the use of these common structural elements for a new family of potassium-channel activating drugs. They also serve as the framework of a range of tannins, which are becoming increasingly important because of their health-promoting effects found in teas, vegetables, fruits, fruit juices, and red wines. Despite the several existing methods for the synthesis of chromene derivatives, there still is demand for general strategies which can efficiently provide variously substituted chromene systems. In this note, we report a practical and highly efficient procedure for preparing diverse chromene derivatives using ring-closing metathesis (RCM), a methodology emerging as a new tool in synthetic organic chemistry
Item Type: | Article | |||||||||
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Additional Information: | © 1998 American Chemical Society. Received July 3, 1997. This research was supported by National Institute of Health. | |||||||||
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Issue or Number: | 3 | |||||||||
DOI: | 10.1021/jo9712198 | |||||||||
Record Number: | CaltechAUTHORS:20180720-153948239 | |||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20180720-153948239 | |||||||||
Official Citation: | A Highly Efficient and Practical Synthesis of Chromene Derivatives Using Ring-Closing Olefin Metathesis Sukbok Chang and Robert H. Grubbs The Journal of Organic Chemistry 1998 63 (3), 864-866 DOI: 10.1021/jo9712198 | |||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
ID Code: | 88096 | |||||||||
Collection: | CaltechAUTHORS | |||||||||
Deposited By: | George Porter | |||||||||
Deposited On: | 23 Jul 2018 21:24 | |||||||||
Last Modified: | 16 Nov 2021 00:23 |
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