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A Highly Efficient and Practical Synthesis of Chromene Derivatives Using Ring-Closing Olefin Metathesis

Chang, Sukbok and Grubbs, Robert H. (1998) A Highly Efficient and Practical Synthesis of Chromene Derivatives Using Ring-Closing Olefin Metathesis. Journal of Organic Chemistry, 63 (3). pp. 864-866. ISSN 0022-3263. https://resolver.caltech.edu/CaltechAUTHORS:20180720-153948239

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Abstract

Chromenes (2H-1-benzopyran derivatives) have been widely employed as important intermediates in the synthesis of many natural products and medicinal agents. There has been recent interest in the use of these common structural elements for a new family of potassium-channel activating drugs. They also serve as the framework of a range of tannins, which are becoming increasingly important because of their health-promoting effects found in teas, vegetables, fruits, fruit juices, and red wines. Despite the several existing methods for the synthesis of chromene derivatives, there still is demand for general strategies which can efficiently provide variously substituted chromene systems. In this note, we report a practical and highly efficient procedure for preparing diverse chromene derivatives using ring-closing metathesis (RCM), a methodology emerging as a new tool in synthetic organic chemistry


Item Type:Article
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https://dx.doi.org/10.1021/jo9712198DOIArticle
https://pubs.acs.org/doi/suppl/10.1021/jo9712198PublisherSupporting Information
ORCID:
AuthorORCID
Grubbs, Robert H.0000-0002-0057-7817
Additional Information:© 1998 American Chemical Society. Received July 3, 1997. This research was supported by National Institute of Health.
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Issue or Number:3
Record Number:CaltechAUTHORS:20180720-153948239
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180720-153948239
Official Citation:A Highly Efficient and Practical Synthesis of Chromene Derivatives Using Ring-Closing Olefin Metathesis Sukbok Chang and Robert H. Grubbs The Journal of Organic Chemistry 1998 63 (3), 864-866 DOI: 10.1021/jo9712198
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:88096
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:23 Jul 2018 21:24
Last Modified:03 Oct 2019 20:03

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