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A Practical Synthesis of L-Azatyrosine

Myers, Andrew G. and Gleason, James L. (1996) A Practical Synthesis of L-Azatyrosine. Journal of Organic Chemistry, 61 (2). pp. 813-815. ISSN 0022-3263. http://resolver.caltech.edu/CaltechAUTHORS:20180720-155648203

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Abstract

Oncogenic Ras genes and the G-proteins which they encode are important targets for anticancer research. Ras proteins have been implicated to function as components of the cellular signal transduction pathways related to cell proliferation and differentiation. In their oncogenic form, the natural GTP-ase activity of Ras proteins is inhibited, leading to overstimulation of the signaling pathway for cell growth. The potential importance of oncogenic Ras genes and gene products as targets for cancer chemotherapy is underscored by the observation that up to 40% of human colon tumors and 95% of human pancreatic tumors have been found to contain oncogenic Ras genes.


Item Type:Article
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https://dx.doi.org/10.1021/jo9515079DOIArticle
Additional Information:© 1996 American Chemical Society. Received August 14, 1995. This research was generously supported by the National Science Foundation and the National Institutes of Health. J.L.G. acknowledges postdoctoral fellowship support from the National Institutes of Health.
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NIH Postdoctoral FellowshipUNSPECIFIED
Record Number:CaltechAUTHORS:20180720-155648203
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20180720-155648203
Official Citation:A Practical Synthesis of l-Azatyrosine Andrew G. Myers and James L. Gleason The Journal of Organic Chemistry 1996 61 (2), 813-815 DOI: 10.1021/jo9515079
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:88100
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:23 Jul 2018 21:35
Last Modified:23 Jul 2018 21:35

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