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Chemistry Takes a Bath: Reactions in Aqueous Media

Romney, David K. and Arnold, Frances H. and Lipshutz, Bruce H. and Li, Chao-Jun (2018) Chemistry Takes a Bath: Reactions in Aqueous Media. Journal of Organic Chemistry, 83 (14). pp. 7319-7322. ISSN 0022-3263. doi:10.1021/acs.joc.8b01412.

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Chemical reactions in water underpin the very existence of life. But to synthetic chemists, water is usually considered an enemy, lurking in the shadows, waiting to reduce yields and destroy reproducibility. Indeed, chemists often take great pains to exclude even traces of water from their reaction media, and if water does make an appearance in a synthetic procedure, it is only in the course of workup. Instead, fine-chemical syntheses tend to use petroleum-derived solvents, which contribute to a vast pool of toxic waste,(1,2) and water-sensitive reactions, which complicate process development and oftentimes create safety hazards.(3) Thus, there has been an increasing push in industry and academia to replace reactions run in traditional organic solvents with alternatives that function in aqueous media.

Item Type:Article
Related URLs:
URLURL TypeDescription
Romney, David K.0000-0003-0498-7597
Arnold, Frances H.0000-0002-4027-364X
Lipshutz, Bruce H.0000-0001-9116-7049
Li, Chao-Jun0000-0002-3859-8824
Additional Information:© 2018 American Chemical Society. Published: July 20, 2018. This article is part of the Organic and Biocompatible Transformations in Aqueous Media special issue.
Issue or Number:14
Record Number:CaltechAUTHORS:20180723-085717756
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Official Citation:Chemistry Takes a Bath: Reactions in Aqueous Media. David K. Romney, Frances H. Arnold, Bruce H. Lipshutz, and Chao-Jun Li. The Journal of Organic Chemistry 2018 83 (14), 7319-7322 DOI: 10.1021/acs.joc.8b01412
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:88115
Deposited By: Tony Diaz
Deposited On:23 Jul 2018 16:35
Last Modified:16 Nov 2021 00:24

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