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The Reaction of Simple Antigens with Purified Antibody

Pardee, Arthur B. and Pauling, Linus (1949) The Reaction of Simple Antigens with Purified Antibody. Journal of the American Chemical Society, 71 (1). pp. 143-148. ISSN 0002-7863. doi:10.1021/ja01169a039.

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In the present paper we report the results of experiments on the interaction of simple precipitating antigens with purified antibody solutions. It has been found that the behavior of the simple antigens with purified antibody solutions is somewhat different from that with antiserum, the difference apparently being due to a rather strong non-specific combination of the dye molecules with the constituents of serum not present in purified antibody, presumably mainly albumin. The effect of this combination seems to be to reduce the concentration of the free dye molecules to such an extent that in serum solution they react mainly in the monomeric form.

Item Type:Article
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Additional Information:© 1949 American Chemical Society. Received June 7, 1948.
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Gates and Crellin Laboratories of Chemistry1135
Issue or Number:1
Record Number:CaltechAUTHORS:20180724-121639266
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Official Citation:The Reaction of Simple Antigens with Purified Antibody Arthur B. Pardee and Linus. Pauling Journal of the American Chemical Society 1949 71 (1), 143-148 DOI: 10.1021/ja01169a039
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:88182
Deposited By: George Porter
Deposited On:24 Jul 2018 21:27
Last Modified:16 Nov 2021 00:24

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