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The Reactions of Antiserum Homologous to the 4-Azophthalate Ion

Pressman, David and Pauling, Linus (1949) The Reactions of Antiserum Homologous to the 4-Azophthalate Ion. Journal of the American Chemical Society, 71 (8). pp. 2893-2899. ISSN 0002-7863. doi:10.1021/ja01176a092.

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In connection with our studies on the nature of the forces operating in the combination of haptens with hapten-homologous antisera it became apparent that a study should be made of an antiserum prepared against a haptenic group containing two or more discrete negative charges, in order to determine the difference in combining power with this antibody of substances containing a single negative charge and substances containing two charges. Great specificity for the charged group has been observed for singly charged haptenic groups: thus benzenesulfonate ion and benzenearsonate ion were found not to combine with antibodies homologous to the benzoate ion group, and benzenesulfonate ion and benzoate ion were found not to combine with antibodies to the benzenearsonate ion group; but when the ions are very closely related, as are benzenephosphonate ion and benzenearsonate ion, there is appreciable cross reaction. We were interested to discover whether antibodies homologous to haptenic groups containing two charges would show greater or less specificity than was shown by these antibodies.

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Additional Information:© 1949 American Chemical Society. Received March 29, 1949. This investigation was carried out with the aid of a grant from The Rockefeller Foundation. We wish to thank Mr. Dan Rice for assisting with the analytical work.
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Rockefeller FoundationUNSPECIFIED
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Gates and Crellin Laboratories of Chemistry1228
Issue or Number:8
Record Number:CaltechAUTHORS:20180724-121639413
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Official Citation:The Reactions of Antiserum Homologous to the 4-Azophthalate Ion David. Pressman and Linus. Pauling Journal of the American Chemical Society 1949 71 (8), 2893-2899 DOI: 10.1021/ja01176a092
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:88184
Deposited By: George Porter
Deposited On:24 Jul 2018 21:34
Last Modified:16 Nov 2021 00:24

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