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Studies on the Denaturation of Antibody. III. Kinetic Aspects of the Inactivation of Diphtheria Antitoxin by Urea

Wright, George G. and Schomaker, Verner (1948) Studies on the Denaturation of Antibody. III. Kinetic Aspects of the Inactivation of Diphtheria Antitoxin by Urea. Journal of the American Chemical Society, 70 (1). pp. 356-364. ISSN 0002-7863. https://resolver.caltech.edu/CaltechAUTHORS:20180724-121639493

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Abstract

In the present investigation we have studied the effects of pH, urea concentration, and temperature on the inactivation reaction, in order to explore the influence of these factors on its abnormalities. The experimental results are shown to be compatible with a simple kinetic mechanism.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1021/ja01181a111DOIArticle
Additional Information:© 1948 American Chemical Society. Received July 2, 1947. This investigation was carried out with the aid of a grant from The Rockefeller Foundation. The authors are indebted to Professor Linus Pauling for suggestions and discussion, to J. Y. Chien for carrying out preliminary experiments on the effect of temperature, and to Sharp and Dohme, Glenolden, Pennsylvania, for supplying the antitoxin and toxin
Funders:
Funding AgencyGrant Number
Rockefeller FoundationUNSPECIFIED
Other Numbering System:
Other Numbering System NameOther Numbering System ID
Gates and Crellin Laboratories of Chemistry1072
Issue or Number:1
Record Number:CaltechAUTHORS:20180724-121639493
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180724-121639493
Official Citation:Studies on the Denaturation of Antibody. III. Kinetic Aspects of the Inactivation of Diphtheria Antitoxin by Urea George G. Wright and Verner Schomaker Journal of the American Chemical Society 1948 70 (1), 356-364 DOI: 10.1021/ja01181a111
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:88185
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:24 Jul 2018 21:37
Last Modified:03 Oct 2019 20:03

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