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Recent findings regarding let-7 in immunity

Jiang, Shuai (2018) Recent findings regarding let-7 in immunity. Cancer Letters, 434 . pp. 130-131. ISSN 0304-3835.

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Let-7 was one of the first microRNAs discovered in Caenorhabditis elegans. It exerts various biological functions, and shows strong evolutionary conservation from nematodes to humans. Recent research findings identify the let-7 cluster as a crucial player in the regulation of B-cell antibody production and macrophage responses. Since increasing evidence supports the let-7 cluster's role in immune system regulation, here we review the latest knowledge regarding the activities of let-7 in both innate and adaptive immune cells—including macrophages, B cells, and subsets of T cells—and the targets regulated by members of the let-7 family. This summary of knowledge acquired from collective studies will help guide future physiological and pathological studies to further elucidate the potential uses of this microRNA in immunity and other different biological outputs.

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Additional Information:© 2018 Elsevier B.V. Received 29 June 2018, Revised 18 July 2018, Accepted 18 July 2018, Available online 24 July 2018.
Record Number:CaltechAUTHORS:20180724-134720810
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Official Citation:Shuai Jiang, Recent findings regarding let-7 in immunity, Cancer Letters, Volume 434, 2018, Pages 130-131, ISSN 0304-3835, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:88196
Deposited By: Tony Diaz
Deposited On:24 Jul 2018 20:53
Last Modified:06 Aug 2018 16:25

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