Wang, Jianling and Larsen, Randy W. and Chan, Sunney I. and Boldt, Nancy J. and Ondrias, Mark R. (1992) Ligand photodissociation and recombination dynamics of ferrous cytochrome c peroxidase at alkaline pH. Journal of the American Chemical Society, 114 (4). pp. 1487-1488. ISSN 0002-7863. doi:10.1021/ja00030a057. https://resolver.caltech.edu/CaltechAUTHORS:20180724-152024973
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Abstract
The dynamics associated with ligand photodissociation and ligand binding provide an avenue through which information concerning conformational interactions involving the active site of heme proteins may be obtained. To date, most time-resolved spectroscopic investigations have involved exogenous π-acceptor ligands such as CO, O_2, and NO. In fact, until very recently hexacoordinate low-spin hemes with strong-field σ-donor ligands were considered to be largely nonphotolabile. Magda and coworkers have, however, demonstrated that both cytochrome c and cytochrome b_5 exhibit photodissociation of nitrogenous ligands on a very fast (< 100 ps) time scale. Photodissociation of a σ ligand has also been implicated in the photodynamics of the cytochrome a_3 distal heme pocket in cytochrome c oxidase. This study characterizes the dynamics of the low-spin alkaline form of ferrous cytochrome c peroxidase (CCP) subsequent to heme photodissociation.
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Additional Information: | © 1992 American Chemical Society. Received October 18, 1991. We gratefully acknowledge the financial support of the National Institutes of Health [GM33330 (M.R.O.) and GM22432 (S.I.C.)]. | ||||||
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Issue or Number: | 4 | ||||||
DOI: | 10.1021/ja00030a057 | ||||||
Record Number: | CaltechAUTHORS:20180724-152024973 | ||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20180724-152024973 | ||||||
Official Citation: | Ligand photodissociation and recombination dynamics of ferrous cytochrome c peroxidase at alkaline pH Jianling Wang, Randy W. Larsen, Sunney I. Chan, Nancy J. Boldt, and Mark R. Ondrias Journal of the American Chemical Society 1992 114 (4), 1487-1488 DOI: 10.1021/ja00030a057 | ||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
ID Code: | 88210 | ||||||
Collection: | CaltechAUTHORS | ||||||
Deposited By: | George Porter | ||||||
Deposited On: | 24 Jul 2018 22:52 | ||||||
Last Modified: | 16 Nov 2021 00:24 |
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