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On a phospho-tri-anhydride formula for the nucleic acids

Pauling, Linus and Schomaker, Verner (1952) On a phospho-tri-anhydride formula for the nucleic acids. Journal of the American Chemical Society, 74 (14). pp. 3712-3713. ISSN 0002-7863. doi:10.1021/ja01134a527.

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Last year Dr. Edward Ronwin suggested a phospho-tri-anhydride formula for the nucleic acids, with as its core a polymer chain of phosphorus atoms held together by oxygen atoms, each phosphorus atom having five oxygen atoms attached to it, of which three bind it to adjacent phosphorus atoms, one is in a hydroxyl group, and one is in a sugar ester group. We then stated that in formulating a hypothetical structure for a substance one must take care that the structural elements of which use is made are reasonable ones or one must show that there is an overwhelming necessity for a radical proposal, that there is no precedent for a structure in which phosphorus is bonded to five oxygen atoms, that in every one of the scores of quinque-positive phosphorus compounds that have been subjected to complete structural investigation the phosphorus atom is surrounded by four oxygen atoms, and that the ligation of five oxygen atoms about each phosphorus atom is such an unlikely structural feature that the proposed phospho-trianhydride formula for the nucleic acids deserves no serious consideration.

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Additional Information:© 1952 American Chemical Society. Received June 7, 1952.
Issue or Number:14
Record Number:CaltechAUTHORS:20180725-111210227
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Official Citation:ON A PHOSPHO-TRI-ANHYDRIDE FORMULA FOR THE NUCLEIC ACIDS Linus Pauling and Verner Schomaker Journal of the American Chemical Society 1952 74 (14), 3712-3713 DOI: 10.1021/ja01134a527
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:88253
Deposited By: George Porter
Deposited On:25 Jul 2018 20:43
Last Modified:16 Nov 2021 00:25

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