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The Serological Properties of Simple Substances. I. Precipitation Reactions between Antibodies and Substances Containing Two or More Haptenic Groups

Pauling, Linus and Pressman, David and Campbell, Dan H. and Ikeda, Carol and Ikawa, Miyoshi (1942) The Serological Properties of Simple Substances. I. Precipitation Reactions between Antibodies and Substances Containing Two or More Haptenic Groups. Journal of the American Chemical Society, 64 (12). pp. 2994-3003. ISSN 0002-7863. http://resolver.caltech.edu/CaltechAUTHORS:20180727-101438826

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Abstract

The problem of obtaining from precipitation experiments evidence about the structure of antibodies and the nature of serological reactions is obviously greatly simplified by the replacement of protein antigens by simple substances of known structure. For this reason we began and are carrying on an extensive program of investigation of the reactions of simple substances with antisera. In this paper we report the quantitative study of the precipitin reaction for twenty simple substances containing two or more haptenic groups, and the results of tests of seven substances containing one group. It is found that the observations support the framework theory of serological precipitates.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1021/ja01264a080DOIArticle
Additional Information:© 1942 American Chemical Society. Received July 6, 1942. We are grateful to the Rockefeller Foundation for financial support of this work. We wish to thank Mr. Paul Faust and Mr. Shelton Steinle for their assistance in carrying out analyses, and Mr. David Brown for the preparation of phenylarsonic acid.
Funders:
Funding AgencyGrant Number
Rockefeller FoundationUNSPECIFIED
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Other Numbering System NameOther Numbering System ID
Gates and Crellin Laboratories of Chemistry885
Record Number:CaltechAUTHORS:20180727-101438826
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20180727-101438826
Official Citation:The Serological Properties of Simple Substances. I. Precipitation Reactions between Antibodies and Substances Containing Two or More Haptenic Groups Linus Pauling, David Pressman, Dan H. Campbell, Carol Ikeda, and Miyoshi Ikawa Journal of the American Chemical Society 1942 64 (12), 2994-3003 DOI: 10.1021/ja01264a080
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:88330
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:30 Jul 2018 18:39
Last Modified:30 Jul 2018 18:39

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