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The Serological Properties of Simple Substances. III. The Composition of Precipitates of Antibodies and Polyhaptenic Simple Substances; the Valence of Antibodies

Pauling, Linus and Pressman, David and Ikeda, Carol (1942) The Serological Properties of Simple Substances. III. The Composition of Precipitates of Antibodies and Polyhaptenic Simple Substances; the Valence of Antibodies. Journal of the American Chemical Society, 64 (12). pp. 3010-3014. ISSN 0002-7863. http://resolver.caltech.edu/CaltechAUTHORS:20180727-101439011

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Abstract

The antibody-antigen mole ratio of precipitates formed by interaction of antigens and homologous antisera provides information about the relative combining powers or “valences” of antigen and antibody molecules. For protein antigens it has been found by Heidelberger and co-workers and by other investigators that the antibody-antigen mole ratio is greater than unity, and increases from the antigen-excess region (where the values approach unity) through the equivalence zone to the antibody-excess region, the values for the last region being nearly twice those for the equivalence zone. These results, which show that the effective valence of the protein antigen molecules is greater than that of the antibody molecules, have been accounted for in a reasonable way by the framework theory and the postulate that antibodies which act as precipitins are bivalent. Since the mole ratio gives only the relative valences of antigen and antibody, and information about the valence of protein antigens is in general not at hand, these data do not directly provide information about the valence of the antibodies; but similar data for simple antigens of known structure should give this information. In this paper, the third in a series of studies of the serological properties of simple substances, we present and discuss the results of about 400 analyses of precipitates formed by antibodies and polyhaptenic substances.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1021/ja01264a082DOIArticle
Additional Information:© 1942 American Chemical Society. Received July 6, 1942. We thank the Rockefeller Foundation for support of the work reported in this paper, and Mr. Shelton Steinle and Mrs. Elizabeth Swingle for carrying out analyses
Funders:
Funding AgencyGrant Number
Rockefeller FoundationUNSPECIFIED
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Gates and Crellin Laboratories of Chemistry887
Record Number:CaltechAUTHORS:20180727-101439011
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20180727-101439011
Official Citation:The Serological Properties of Simple Substances. III. The Composition of Precipitates of Antibodies and Polyhaptenic Simple Substances; the Valence of Antibodies Linus Pauling, David Pressman, and Carol Ikeda Journal of the American Chemical Society 1942 64 (12), 3010-3014 DOI: 10.1021/ja01264a082
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:88332
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:30 Jul 2018 21:40
Last Modified:30 Jul 2018 21:40

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