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The Serological Properties of Simple Substances. IV. Hapten Inhibition of Precipitation of Antibodies and Polyhaptenic Simple Substances

Pressman, David and Brown, David H. and Pauling, Linus (1942) The Serological Properties of Simple Substances. IV. Hapten Inhibition of Precipitation of Antibodies and Polyhaptenic Simple Substances. Journal of the American Chemical Society, 64 (12). pp. 3015-3020. ISSN 0002-7863. http://resolver.caltech.edu/CaltechAUTHORS:20180727-101439113

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Abstract

As part of a series of studies of the antigenantibody reaction by use of polyhaptenic simple substances as antigens,we have made a quantitative investigation of the ability of various substituted phenylarsonic acids to inhibit the precipitation of compounds containing two or more phenylarsonic acid groups with antiserum to sheep serum coupled with diazotized p-arsanilic acid. The investigation included study of the effect of various concentrations of hapten XXIII ([chemical structure]) on the amount of precipitate obtained with antiserum and various concentrations of antigen VI [chemical structure], where R is the p-azophenylarsonic acid group); the effect of changed conditions of precipitation for the same system; the effects of four haptens on the precipitation of each of five antigens and each of two pools of antiserum; and the effects of 24 different haptens on one precipitin reaction. The results are discussed in this paper.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1021/ja01264a083DOIArticle
Additional Information:© 1942 American Chemical Society. Received August 10, 1942. This investigation was carried out with the aid of a grant from the Rockefeller Foundation. Mrs. Elizabeth Swingle, Mr. Frank Lanni, Mr. Stanley Swingle, and Mr. Shelton Steinle assisted with the analyses.
Funders:
Funding AgencyGrant Number
Rockefeller FoundationUNSPECIFIED
Other Numbering System:
Other Numbering System NameOther Numbering System ID
Gates and Crellin Laboratories of Chemistry907
Record Number:CaltechAUTHORS:20180727-101439113
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20180727-101439113
Official Citation:The Serological Properties of Simple Substances. IV. Hapten Inhibition of Precipitation of Antibodies and Polyhaptenic Simple Substances David Pressman, David H. Brown, and Linus Pauling Journal of the American Chemical Society 1942 64 (12), 3015-3020 DOI: 10.1021/ja01264a083
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:88333
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:30 Jul 2018 21:34
Last Modified:30 Jul 2018 21:34

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