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Sensitivity, polarity, and conductance change in the response of vertebrate hair cells to controlled mechanical stimuli

Hudspeth, A. J. and Corey, D. P. (1977) Sensitivity, polarity, and conductance change in the response of vertebrate hair cells to controlled mechanical stimuli. Proceedings of the National Academy of Sciences of the United States of America, 74 (6). pp. 2407-2411. ISSN 0027-8424.

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Hair cells, the primary receptors of the auditory, vestibular, and lateral-line sensory systems, produce electrical signals in response to mechanical stimulation of their apical hair bundles. We employed an in vitro preparation and intracellular recording to investigate the transduction mechanism of hair cells in the sacculus from the inner ear of the bull-frog (Rana catesbeiana). When stimulated directly by mechanical deflection of their hair bundles, these cells gave graded responses up to 15 mV in amplitude; the peak sensitivity was about 20 mV/µm deflection. The depolarizing component of the receptor potential corresponded to stimuli directed towards the kinocilium. Depolarizing responses were associated with a membrane resistance decrease, and hyperpolarizing responses with a resistance increase. Action potentials, possibly calcium spikes, were occasionally evoked in hair cells by mechanical or electrical stimulation.

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Additional Information:© 1977 by the National Academy of Sciences. Communicated by Max Delbrück, April 18, 1977. We thank Mr. J. Bixby and Drs. S. Benzer, M. Delbrück, M. Igarashi, W. Quinn, and D. Van Essen for comments on the manuscript. This project was supported by U.S. Public Health Service Grant NS-13154 and by grants from the Alfred P. Sloan Foundation and the Ann Peppers Foundation. The costs of publication of this article were defrayed in part by the payment of page charges from funds made available to support the research which is the subject of the article. This article must therefore be hereby marked "advertisement" in accordance with 18 U. S. C. §1734 solely to indicate this fact.
Subject Keywords:sensory transduction; intracellular recording; amphibian; sacculus; action potential
Issue or Number:6
Record Number:CaltechAUTHORS:HUDpnas77
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:8834
Deposited By: Tony Diaz
Deposited On:20 Sep 2007
Last Modified:02 Oct 2019 23:54

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