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Evidence for an interrelation in the metabolism of lysine, arginine and pyrimidines in Neurospora

Houlahan, Mary B. and Mitchell, Herschel K. (1948) Evidence for an interrelation in the metabolism of lysine, arginine and pyrimidines in Neurospora. Proceedings of the National Academy of Sciences of the United States of America, 34 (10). pp. 465-470. ISSN 0027-8424.

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The behavior of a strain of Neurospora crassa carrying the pyrimidineless gene 3a (37301) and s, a second mutant gene which suppresses the effect of 3a, has been described briefly in an earlier publication.(1) A strain carrying 3a alone has an absolute requirement for pyrimidine, while 3a-s reaches about one-half the maximum growth of the wild type on the un-supplemented basal medium.(2) However, if arginine is present in this medium the pyrimidine requirement is again manifested. The effect of arginine may be suppressed in turn by the addition of lysine. This response to arginine and lysine suggested the possibility that one or both of these amino acids are involved in the biosynthesis of pyrimidines. More recent investigations have provided evidence that a relationship does exist, but its nature is not yet understood.

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Additional Information:© 1948 by the National Academy of Sciences. Communicated by G. W. Beadle, July 27, 1948. Work supported by grants from the Rockefeller Foundation.
Issue or Number:10
Record Number:CaltechAUTHORS:HOUpnas48
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:8853
Deposited By: Tony Diaz
Deposited On:21 Sep 2007
Last Modified:02 Oct 2019 23:54

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