Integrated Micro/Nano Fluidics for Mass-spectrometry Protein Analysis

Abstract

Over the past decade there has been increasing interest in the development of miniaturized chemical analysis systems using MEMS technology to handle a small amount of liquid from mL down to nL, or even pL. However, due to the diversified process of chemical/biochemical analysis and a wide range of samples involved, a self-contained mass-produced lab-on-a-chip with the same economy of scale as electrical components has yet to be realized. Here, we report an effort to produce such a chip that can couple to a mass spectrometer for biomolecule analysis.