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Multimodal Prussian blue analogs as contrast agents for X-ray computed tomography

Promdet, Premrudee and Rodríguez-García, Bárbara and Henry, Alexandria and Nguyen, Cathie and Khuu, Thien and Galan-Mascaros, Jose-Ramon and Sorasaenee, Karn (2018) Multimodal Prussian blue analogs as contrast agents for X-ray computed tomography. Dalton Transactions, 47 (34). pp. 11960-11967. ISSN 1477-9226.

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Prussian blue analogs (PBAs) are versatile materials with a wide range of applications. Due to their tunability, intrinsic biocompatibility, as well as low toxicity, these nanoscale coordination polymers have been successfully studied as multimodal contrast agents for multiple imaging techniques. Herein, we report the expanded biomedical application of PBAs to X-ray computed tomography (CT). In our systematic study of the series A{Mn^(II)[Fe^(III)(CN)6]} (A = K^+, Rb^+, Cs^+), we showed that derivatives incorporating Rb+ and Cs+ ions in the tetrahedral sites of the parent face-centered cubic cyano-bridged networks exhibited substantially increased X-ray attenuation coefficients, thus yielding significant contrast compared to the clinically approved X-ray contrast agent iohexol at the same concentrations. Additionally, our μ-CT studies revealed that these PBAs could be useful as dual-energy CT contrast agents for different biological specimens by using the lower varying scanning X-ray tube voltages. Finally, in vitro studies using U87-Luc cells treated with PBAs, including cellular CT imaging and bioluminescence cell viability assays, revealed that PBAs were taken up by the glioblastoma cells, with moderate biocompatibility at concentrations below the mM range.

Item Type:Article
Related URLs:
URLURL TypeDescription Information
Galan-Mascaros, Jose-Ramon0000-0001-7983-9762
Sorasaenee, Karn0000-0002-3364-1918
Additional Information:© 2018 The Royal Society of Chemistry. The article was received on 27 Apr 2018, accepted on 16 Jul 2018 and first published on 17 Jul 2018. We thank G. Esteban Fernandez for his help with optical imaging. We are thankful to Rex A. Moats and Harvey Pollack for an insightful discussion on X-ray computed tomography experiments. We also thank Gevorg Karapetyan and Seda Mkhitaryan for their assistance with cell culture and bioluminescence cell viability assays. We thank the Radiology Research Fund and TSRI; the European Union (project ERC StG grant CHEMCOMP no 279313); the Spanish Ministerio de Economía y Competitividad (MINECO) through project CTQ2015-71287-R; and the Generalitat de Catalunya (2017-SGR-1406 and the CERCA programme) for their financial support. There are no conflicts to declare.
Funding AgencyGrant Number
Radiology Research FundUNSPECIFIED
European Research Council (ERC)279313
Ministerio de Economía y Competitividad (MINECO)CTQ2015-71287-R
Generalitat de Catalunya2017-SGR-1406
Issue or Number:34
Record Number:CaltechAUTHORS:20180803-095410690
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:88562
Deposited By: Tony Diaz
Deposited On:03 Aug 2018 17:13
Last Modified:03 Oct 2019 20:07

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