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Synthetic cationic glycopolymers for gene delivery

Ahmed, M. and Narain, Ravin (2016) Synthetic cationic glycopolymers for gene delivery. In: Polymers and Nanomaterials for Gene Therapy. Woodhead Publishing , Oxford, pp. 81-98. ISBN 978-0-08-100520-0.

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The development of biocompatible non-toxic vectors for gene delivery purposes is the focus of research, during the last two decades. The modification of cationic polymers with sugar residues is an interesting method to introduce physiological stability to cationic polymers. The development of efficient carbohydrate-based gene delivery vector requires detailed study of glycosylation extent, hydroxyl stereochemistry, type of sugar moiety, DNA condensation efficacies, DNA release, and protection efficacies of these cationic glycopolymers. A variety of well-controlled cationic glycopolymers of varying molecular weights, cationic to carbohydrate contents, shapes, and architectures are prepared by living radical polymerization, condensation polymerization, and post-polymerization conjugation approaches. The gene delivery efficacies of these vectors in vitro and in mice models are evaluated.

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Additional Information:© 2016 Elsevier Ltd. Available online 19 February 2016.
Subject Keywords:Glycosylated cationic polymers; living radical polymerization; glycosylation extent; hydroxyl stereochemistry; lectins; receptors for advanced glycation end products
Record Number:CaltechAUTHORS:20180806-074406184
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Official Citation:M. Ahmed, R. Narain, 4 - Synthetic cationic glycopolymers for gene delivery, Editor(s): Ravin Narain, Polymers and Nanomaterials for Gene Therapy, Woodhead Publishing, 2016, Pages 81-98, ISBN 9780081005200, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:88581
Deposited By: Tony Diaz
Deposited On:06 Aug 2018 16:49
Last Modified:06 Aug 2018 16:49

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