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DNA-mediated electron transfer: Chemistry at a distance

Barton, Jacqueline K. (1998) DNA-mediated electron transfer: Chemistry at a distance. Pure and Applied Chemistry, 70 (4). pp. 873-879. ISSN 0033-4545. doi:10.1351/pac199870040873.

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The DNA double helix, containing a π-stacked array of base pairs in its core, represents a unique and efficient medium for long-range charge transport. DNA assemblies have been constructed containing tethered metallointercalators, and these provide chemically well-defined systems through which to probe the DNA π-stack. Using both spectroscopy and chemical assays of reactivity, we find electron transfer reactions mediated by the DNA base pairs to occur over long molecular distances. The structure of DNA facilitates chemistry at a distance. Importantly, these long-range reactions depend sensitively upon base pair stacking, and hence are modulated by and report on the characteristic stacking within the double helix.

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Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 1998 IUPAC. I am grateful to the NIH for their financial support of this work (GM33309 and GM49216). I am also indebted to my coworkers and collaborators for their efforts in the exploration of this chemistry.
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Issue or Number:4
Record Number:CaltechAUTHORS:20180808-100416627
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:88653
Deposited By: Tony Diaz
Deposited On:08 Aug 2018 17:21
Last Modified:16 Nov 2021 00:28

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