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DNA-mediated electron transfer: Chemistry at a distance

Barton, Jacqueline K. (1998) DNA-mediated electron transfer: Chemistry at a distance. Pure and Applied Chemistry, 70 (4). pp. 873-879. ISSN 0033-4545. https://resolver.caltech.edu/CaltechAUTHORS:20180808-100416627

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Abstract

The DNA double helix, containing a π-stacked array of base pairs in its core, represents a unique and efficient medium for long-range charge transport. DNA assemblies have been constructed containing tethered metallointercalators, and these provide chemically well-defined systems through which to probe the DNA π-stack. Using both spectroscopy and chemical assays of reactivity, we find electron transfer reactions mediated by the DNA base pairs to occur over long molecular distances. The structure of DNA facilitates chemistry at a distance. Importantly, these long-range reactions depend sensitively upon base pair stacking, and hence are modulated by and report on the characteristic stacking within the double helix.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1351/pac199870040873DOIArticle
ORCID:
AuthorORCID
Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 1998 IUPAC. I am grateful to the NIH for their financial support of this work (GM33309 and GM49216). I am also indebted to my coworkers and collaborators for their efforts in the exploration of this chemistry.
Funders:
Funding AgencyGrant Number
NIHGM33309
NIHGM49216
Issue or Number:4
Record Number:CaltechAUTHORS:20180808-100416627
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180808-100416627
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:88653
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:08 Aug 2018 17:21
Last Modified:03 Oct 2019 20:08

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