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Physical organic chemistry in the brain

Dougherty, Dennis A. (1997) Physical organic chemistry in the brain. Pure and Applied Chemistry, 69 (9). pp. 1969-1978. ISSN 0033-4545. doi:10.1351/pac199769091969.

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A new tool for precise structural modification of ion channel proteins - the in vivo nonsense suppression technique for incorporating unnatural amino acids - has been developed. This new tool allows the kind of systematic structure-function correlation studies that are commonly employed in physical organic chemistry to be applied to the important proteins of molecular neurobiology. In particular, the method has been applied to the nicotinic acetylcholine receptor, The differing roles of the numerous aromatic amino acids present at the agonist binding site can be distinguished. In addition, high precision studies of the ion channel region have produced new insights into the channel gating mechanism.

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Dougherty, Dennis A.0000-0003-1464-2461
Additional Information:© 1997 IUPAC. I thank my colleague and collaborator Henry Lester for invaluable contributions to this work. I also thank the many outstanding graduate students and postdocs who have been part of the “unnatural group”. Our work in this area has been supported by the National Institutes of Health (NS34407).
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Issue or Number:9
Record Number:CaltechAUTHORS:20180809-152106261
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Official Citation:Pure and Applied Chemistry, Volume 69, Issue 9, Pages 1969–1978, ISSN (Online) 1365-3075, ISSN (Print) 0033-4545, DOI:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:88718
Deposited By: George Porter
Deposited On:09 Aug 2018 22:29
Last Modified:16 Nov 2021 00:29

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