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Chemistry and biology of asparagine-linked glycosylation

Imperiali, Barbara and O’Connor, Sarah E. and Hendrickson, Tamara L. and Kellenberger, Christine (1999) Chemistry and biology of asparagine-linked glycosylation. Pure and Applied Chemistry, 71 (5). pp. 777-787. ISSN 0033-4545. https://resolver.caltech.edu/CaltechAUTHORS:20180809-152106445

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Abstract

The biosynthesis of glycoprotein conjugates is a complex process that involves the collective action of numerous enzymes. Recent research on the chemistry and biology of asparagine-linked glycosylation in our group has been focused on two specific areas. These are the development of potent inhibitors of oligosaccharyl transferase and the investigation of the conformational consequences of the glycosylation process. Since asparagine-linked glycosylation is an essential eukaryotic process, an understanding of the details of this complex transformation is of utmost importance both to fundamental biochemistry and to a consideration of the mechanisms of homeostatic control.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1351/pac199971050777DOIArticle
Additional Information:© 1999 IUPAC. This research was supported by the National Institutes of Health (GM 39334).
Funders:
Funding AgencyGrant Number
NIHGM 39334
Issue or Number:5
Record Number:CaltechAUTHORS:20180809-152106445
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180809-152106445
Official Citation:Pure and Applied Chemistry, Volume 71, Issue 5, Pages 777–787, ISSN (Online) 1365-3075, ISSN (Print) 0033-4545, DOI: https://doi.org/10.1351/pac199971050777
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:88720
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:09 Aug 2018 22:56
Last Modified:03 Oct 2019 20:09

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