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Anatomy, development, and plasticity of the neurosecretory hypothalamus in zebrafish

Nagpal, Jatin and Herget, Ulrich and Choi, Min K. and Ryu, Soojin (2019) Anatomy, development, and plasticity of the neurosecretory hypothalamus in zebrafish. Cell and Tissue Research, 375 (1). pp. 5-22. ISSN 0302-766X. https://resolver.caltech.edu/CaltechAUTHORS:20180814-074231487

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Abstract

The paraventricular nucleus (PVN) of the hypothalamus harbors diverse neurosecretory cells with critical physiological roles for the homeostasis. Decades of research in rodents have provided a large amount of information on the anatomy, development, and function of this important hypothalamic nucleus. However, since the hypothalamus lies deep within the brain in mammals and is difficult to access, many questions regarding development and plasticity of this nucleus still remain. In particular, how different environmental conditions, including stress exposure, shape the development of this important nucleus has been difficult to address in animals that develop in utero. To address these open questions, the transparent larval zebrafish with its rapid external development and excellent genetic toolbox offers exciting opportunities. In this review, we summarize recent information on the anatomy and development of the neurosecretory preoptic area (NPO), which represents a similar structure to the mammalian PVN in zebrafish. We will then review recent studies on the development of different cell types in the neurosecretory hypothalamus both in mouse and in fish. Lastly, we discuss stress-induced plasticity of the PVN mainly discussing the data obtained in rodents, but pointing out tools and approaches available in zebrafish for future studies. This review serves as a primer for the currently available information relevant for studying the development and plasticity of this important brain region using zebrafish.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1007/s00441-018-2900-4DOIArticle
https://rdcu.be/bhrahPublisherFree ReadCube access
ORCID:
AuthorORCID
Herget, Ulrich0000-0002-4419-1414
Ryu, Soojin0000-0002-7059-0160
Additional Information:© 2018 Springer-Verlag GmbH Germany, part of Springer Nature. Received: 10 May 2018; Accepted: 20 July 2018; First Online: 14 August 2018. This study was funded by the Max Planck Society, the University Medical Center of the Johannes Gutenberg University Mainz, the German Federal Office for Education and Research (Bundesministerium für Bildung und Forschung) grant number 01GQ1404 to S.R., and German Research Foundation (Deutsche Forschungsgemeinschaft) SPP1926 Next Generation Optogenetics grant to S.R. Compliance with ethical standards. The authors declare that they have no conflict of interest.
Funders:
Funding AgencyGrant Number
Max Planck SocietyUNSPECIFIED
Johannes Gutenberg University MainzUNSPECIFIED
Bundesministerium für Bildung und Forschung (BMBF)01GQ1404
Deutsche Forschungsgemeinschaft (DFG)SPP1926
Subject Keywords:Hypothalamus; Paraventricular nucleus; Zebrafish; Stress
Issue or Number:1
Record Number:CaltechAUTHORS:20180814-074231487
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180814-074231487
Official Citation:Nagpal, J., Herget, U., Choi, M.K. et al. Cell Tissue Res (2019) 375: 5. https://doi.org/10.1007/s00441-018-2900-4
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:88791
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:14 Aug 2018 16:36
Last Modified:03 Oct 2019 20:10

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