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Directed enzyme evolution

Farinas, Edgardo T. and Bulter, Thomas and Arnold, Frances H. (2001) Directed enzyme evolution. Current Opinion in Biotechnology, 12 (6). pp. 545-551. ISSN 0958-1669. doi:10.1016/S0958-1669(01)00261-0.

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Laboratory evolutionists continue to generate better enzymes for industrial and research applications. Exciting developments include new biocatalysts for enantioselective carbon–carbon bond formation and fatty acid production in plants. Creative contributions to the repertoire of evolutionary methods will ensure further growth in applications and expand the scope and complexity of biological design problems that can be addressed. Researchers are also starting to elucidate mechanisms of enzyme adaptation and natural evolution by testing evolutionary scenarios in the laboratory.

Item Type:Article
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Arnold, Frances H.0000-0002-4027-364X
Additional Information:© 2001 Elsevier Science Ltd. Available online 8 February 2002. This work was supported by fellowships from the US National Science Foundation DBI-9807460 (ETF) and the Deutsche Forschungsgemeinschaft (TB).
Funding AgencyGrant Number
Deutsche Forschungsgemeinschaft (DFG)UNSPECIFIED
Subject Keywords:directed enzyme evolution; biocatalyst; enzyme adaptation; protein engineering; enzyme performance
Issue or Number:6
Record Number:CaltechAUTHORS:20180822-075727932
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Official Citation:Edgardo T Farinas, Thomas Bulter, Frances H Arnold, Directed enzyme evolution, Current Opinion in Biotechnology, Volume 12, Issue 6, 2001, Pages 545-551, ISSN 0958-1669, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89005
Deposited By: Tony Diaz
Deposited On:22 Aug 2018 15:01
Last Modified:16 Nov 2021 00:31

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