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Engineering new functions and altering existing functions

Shao, Zhixin and Arnold, Frances H. (1996) Engineering new functions and altering existing functions. Current Opinion in Structural Biology, 6 (4). pp. 513-518. ISSN 0959-440X. doi:10.1016/S0959-440X(96)80117-5.

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Structural and mechanistic information, sequence comparisons, and site-directed mutagenesis data continue to provide a basis for the rational design of new protein functions and the alteration of existing functions. Random mutagenesis and ‘directed evolution’ approaches, however, are making significant headway in solving protein engineering problems, proving highly practical for tuning properties such as enzyme substrate specificity.

Item Type:Article
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Arnold, Frances H.0000-0002-4027-364X
Additional Information:© 1996 Published by Elsevier Ltd.
Issue or Number:4
Record Number:CaltechAUTHORS:20180822-084814588
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Official Citation:Zhixin Shao, Frances H Arnold, Engineering new functions and altering existing functions, Current Opinion in Structural Biology, Volume 6, Issue 4, 1996, Pages 513-518, ISSN 0959-440X, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89009
Deposited By: Tony Diaz
Deposited On:22 Aug 2018 16:38
Last Modified:16 Nov 2021 00:31

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