Cirino, Patrick C. and Arnold, Frances H. (2002) Protein engineering of oxygenases for biocatalysis. Current Opinion in Chemical Biology, 6 (2). pp. 130-135. ISSN 1367-5931. doi:10.1016/S1367-5931(02)00305-8. https://resolver.caltech.edu/CaltechAUTHORS:20180822-091542901
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Abstract
Oxygenase enzymes have seen limited practical applications because of their complexity, poor stabilities, and often low catalytic rates. However, their ability to perform difficult chemistry with high selectivity and specificity has kept oxygenases at the forefront of engineering efforts. Growing understanding of structure–function relationships and improved protein engineering methods are paving the way for applications of oxygenases in chemical synthesis and bioremediation.
Item Type: | Article | ||||||||
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Additional Information: | © 2002 Elsevier Science Ltd. Available online 19 March 2002. The authors thank Dr Anton Glieder for his suggestions and the US Office of Naval Research, Maxygen Corporation and the Biotechnology Research and Development Corporation for funding. | ||||||||
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Subject Keywords: | Oxygenase; cytochrome P450; monooxygenase; dioxygenase; CPO; directed evolution | ||||||||
Issue or Number: | 2 | ||||||||
DOI: | 10.1016/S1367-5931(02)00305-8 | ||||||||
Record Number: | CaltechAUTHORS:20180822-091542901 | ||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20180822-091542901 | ||||||||
Official Citation: | Patrick C Cirino, Frances H Arnold, Protein engineering of oxygenases for biocatalysis, Current Opinion in Chemical Biology, Volume 6, Issue 2, 2002, Pages 130-135, ISSN 1367-5931, https://doi.org/10.1016/S1367-5931(02)00305-8. (http://www.sciencedirect.com/science/article/pii/S1367593102003058) | ||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||
ID Code: | 89016 | ||||||||
Collection: | CaltechAUTHORS | ||||||||
Deposited By: | Tony Diaz | ||||||||
Deposited On: | 22 Aug 2018 16:19 | ||||||||
Last Modified: | 16 Nov 2021 00:31 |
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