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Protein engineering of oxygenases for biocatalysis

Cirino, Patrick C. and Arnold, Frances H. (2002) Protein engineering of oxygenases for biocatalysis. Current Opinion in Chemical Biology, 6 (2). pp. 130-135. ISSN 1367-5931. doi:10.1016/S1367-5931(02)00305-8. https://resolver.caltech.edu/CaltechAUTHORS:20180822-091542901

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Abstract

Oxygenase enzymes have seen limited practical applications because of their complexity, poor stabilities, and often low catalytic rates. However, their ability to perform difficult chemistry with high selectivity and specificity has kept oxygenases at the forefront of engineering efforts. Growing understanding of structure–function relationships and improved protein engineering methods are paving the way for applications of oxygenases in chemical synthesis and bioremediation.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/S1367-5931(02)00305-8DOIArticle
ORCID:
AuthorORCID
Cirino, Patrick C.0000-0002-7245-6205
Arnold, Frances H.0000-0002-4027-364X
Additional Information:© 2002 Elsevier Science Ltd. Available online 19 March 2002. The authors thank Dr Anton Glieder for his suggestions and the US Office of Naval Research, Maxygen Corporation and the Biotechnology Research and Development Corporation for funding.
Funders:
Funding AgencyGrant Number
Office of Naval Research (ONR)UNSPECIFIED
Maxygen CorporationUNSPECIFIED
Biotechnology Research and Development CorporationUNSPECIFIED
Subject Keywords:Oxygenase; cytochrome P450; monooxygenase; dioxygenase; CPO; directed evolution
Issue or Number:2
DOI:10.1016/S1367-5931(02)00305-8
Record Number:CaltechAUTHORS:20180822-091542901
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180822-091542901
Official Citation:Patrick C Cirino, Frances H Arnold, Protein engineering of oxygenases for biocatalysis, Current Opinion in Chemical Biology, Volume 6, Issue 2, 2002, Pages 130-135, ISSN 1367-5931, https://doi.org/10.1016/S1367-5931(02)00305-8. (http://www.sciencedirect.com/science/article/pii/S1367593102003058)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89016
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:22 Aug 2018 16:19
Last Modified:16 Nov 2021 00:31

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