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Review: Selective ligand-exchange adsorbents prepared by template polymerization

Vidyasankar, Sundaresan and Dhal, Pradeep K. and Plunkett, Sean D. and Arnold, Frances H. (1995) Review: Selective ligand-exchange adsorbents prepared by template polymerization. Biotechnology and Bioengineering, 48 (5). pp. 431-436. ISSN 0006-3592. https://resolver.caltech.edu/CaltechAUTHORS:20180822-140726758

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Abstract

Highly selective ligand‐exchange absorbents have been prepared by template polymerization, a process in which the target molecule serves as a template for assembly of specific recognition sites. In an effort to develop materials suitable for chromatographic separations, thin coatings of the selctive templated polymers have been grafted to two reactive macroporous supports, poly(trimethylolpropane trimethacrylate) (TRIM), and propylmethacrylate‐derivatized silica beads. The precursor polymer prepared from the trifunctioal TRIM monomer is macroporous and highly crosslinked, providing a stable structure for surface grafting. The TRIM precursor polymer and various surface‐grafted copolymers have been characterized by scanning electron microscopy (SEM) and IR, ^(13)C NMR, and XPS spectroscopic techniques. Composite adsorbents have also been prepared using propylmethacrylate‐modified silica particles. While equilibrium rebinding selectivites for both types of surface‐templated materials are similar to those reported previously for bulk‐polymerized template polymers, the composite materials are far better suited to chromatographic separations. Highly similar bis‐imidazole substrates can be separated by ligand‐exchange chromatography on these new templated adsorbents.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1002/bit.260480504DOIArticle
ORCID:
AuthorORCID
Dhal, Pradeep K.0000-0002-7059-855X
Arnold, Frances H.0000-0002-4027-364X
Additional Information:© 1995 John Wiley & Sons. Manuscript received: 22 November 1994. Manuscript accepted: 19 June 1995.
Subject Keywords:metal‐ligand coordination; molecular recognition; surface modification; molecular imprinting
Issue or Number:5
Record Number:CaltechAUTHORS:20180822-140726758
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180822-140726758
Official Citation:Vidyasankar, S. , Dhal, P. K., Plunkett, S. D. and Arnold, F. H. (1995), Review: Selective ligand‐exchange adsorbents prepared by template polymerization. Biotechnol. Bioeng., 48: 431-436. doi:10.1002/bit.260480504
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89044
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:22 Aug 2018 22:43
Last Modified:03 Oct 2019 20:12

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